Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Development of a Morphine Pharmacokinetic and Pharmacodynamic Model for the Neonatal Population

Phase 1

Withdrawn

Conditions: Pain
Drug Effect

Interventions: Drug: Morphine

First Posted Date: 2017-01-30

Last Posted Date: 2020-02-25

Lead Sponsor: The Hospital for Sick Children

Registration Number: NCT03035578

Morphine and/or Nalbuphine as Adjuvants in Ultrasound Guided Interscalene Block: for Shoulder Surgeries

Phase 2

Conditions: Rotator Cuff Tear

Interventions: Drug: Morphine
Drug: Nalbuphine
Drug: Bupivacaine 0.5%

First Posted Date: 2017-01-27

Last Posted Date: 2017-05-22

Lead Sponsor: Assiut University

Target Recruit Count: 80

Registration Number: NCT03034382

Locations: 🇪🇬
Assiut University Hospitals, Assiut, Egypt

Effect of Intrathecal Morphine, Dexmedetomidine or Both in Combination to Bupivacaine on Immunity

Phase 1

Conditions: Immune System Suppression

Interventions: Drug: Dexmedetomidine
Drug: Morphine Sulfate
Drug: Bupivacaine

First Posted Date: 2017-01-19

Last Posted Date: 2021-01-14

Lead Sponsor: Assiut University

Target Recruit Count: 30

Registration Number: NCT03024957

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Low-dose Ketamine for Acute Pain in the Emergency Department

Phase 1

Conditions: Pain

Interventions: Drug: Ketamine
Drug: Placebos
Drug: Morphine

First Posted Date: 2017-01-11

Last Posted Date: 2017-01-31

Lead Sponsor: Faculty of Medicine, Sousse

Target Recruit Count: 125

Registration Number: NCT03017248

Locations: 🇹🇳
Faculty of medicine of Sousse, Sousse, Tunisia

Cortical Modulation of Acute Post-thoracotomy Pain With Transcranial Direct Current Stimulation

Phase 2

Completed

Conditions: Pain, Postoperative

Interventions: Device: Transcranial direct current stimulation
Drug: Morphine

First Posted Date: 2016-12-29

Last Posted Date: 2018-03-29

Lead Sponsor: Military Medical Academy, Belgrade, Serbia

Target Recruit Count: 62

Registration Number: NCT03005548

Locations: 🇷🇸
Military Medical Academy, Department of Anesthesiology, Belgrade, Serbia

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

Phase 4

Completed

Conditions: Pain, Postoperative
Ankle Fractures

Interventions: Drug: Ropivacaine
Drug: Epinephrine
Drug: Morphine
Drug: 0.9% sodium chloride solution

First Posted Date: 2016-11-18

Last Posted Date: 2023-12-15

Lead Sponsor: University of Iowa

Target Recruit Count: 100

Registration Number: NCT02967172

Locations: 🇺🇸
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint

Phase 2

Conditions: Knee Arthritis

Interventions: Drug: Morphine Sulfate
Drug: Triamcinolone
Drug: placebo

First Posted Date: 2016-11-18

Last Posted Date: 2021-08-03

Lead Sponsor: Hildrun Haibel

Target Recruit Count: 112

Registration Number: NCT02967302

Locations: 🇩🇪
Charité CBF Rheumatology, Berlin, Germany

Does Local Morphine Add to Local Anesthetics in Serratus Anterior Plane Block Has a System Analgesic Effect?

Not Applicable

Completed

Conditions: Postoperative Complications

Interventions: Drug: Morphine Sulfate
Drug: Bupivacaine Hydrochloride

First Posted Date: 2016-11-11

Last Posted Date: 2020-01-22

Lead Sponsor: Fatma Adel El sherif,MD

Target Recruit Count: 40

Registration Number: NCT02962024

Locations: 🇪🇬
South Egypt Cancer Instuite, Assuit, Egypt

Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery

First Posted Date: 2016-11-08

Last Posted Date: 2017-03-20

Lead Sponsor: University of Illinois College of Medicine at Peoria

Target Recruit Count: 80

Registration Number: NCT02958566

Locations: 🇺🇸
Uicomp, Peoria, Illinois, United States

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Placebo
Drug: pregabalin
Drug: Etoricoxib
Drug: paracetamol
Drug: Morphine
Drug: Ropivacaine

First Posted Date: 2016-11-03

Last Posted Date: 2017-09-14

Lead Sponsor: National University Hospital, Singapore

Target Recruit Count: 116

Registration Number: NCT02954484

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