Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine

Not Applicable

Completed

Conditions: Post Cesarean Pain Management

Interventions: Drug: Tramadol hydrochloride
Drug: Morphine
Drug: Paracetamol
Drug: Diclofenac
Drug: TAB. Percocet (Oxycodone 5MG/Paracetamol 325 MG)

First Posted Date: 2015-05-12

Last Posted Date: 2017-05-09

Lead Sponsor: HaEmek Medical Center, Israel

Target Recruit Count: 200

Registration Number: NCT02440399

Locations: 🇮🇱
Haemek Medical Center, Afula, Israel

Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers

Phase 4

Completed

Conditions: Sickle Cell Crisis
Acute Pain

Interventions: Drug: Low dose ketamine
Drug: Morphine

First Posted Date: 2015-05-06

Last Posted Date: 2016-08-03

Lead Sponsor: Makerere University

Target Recruit Count: 240

Registration Number: NCT02434939

Locations: 🇺🇬
Sickle Cell clinic, Mulago Hospital Complex, Kampala, Uganda

Combined Intrathecal Morphine and Dexmedetomidine Analgesia

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: Dexmedetomidine (Precedex)
Drug: Morphine
Drug: Bupivacaine

First Posted Date: 2015-05-06

Last Posted Date: 2015-05-06

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT02435537

Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain

Not Applicable

Terminated

Conditions: Acute Pain
Fractures

Interventions: Drug: ketamine
Drug: morphine

First Posted Date: 2015-04-30

Last Posted Date: 2019-05-22

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 13

Registration Number: NCT02430818

Locations: 🇺🇸
Barnes Jewish Hospital, Saint Louis, Missouri, United States

Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Drug: Ramosetron
Drug: Naloxone
Drug: saline
Drug: Morphine

First Posted Date: 2015-04-14

Last Posted Date: 2016-02-22

Lead Sponsor: Kyungpook National University Hospital

Target Recruit Count: 90

Registration Number: NCT02416115

Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Morphine
Drug: Ropivacaine

First Posted Date: 2015-04-07

Last Posted Date: 2022-11-08

Lead Sponsor: University Hospital, Grenoble

Target Recruit Count: 101

Registration Number: NCT02410317

Locations: 🇫🇷
Hôpital Couple Enfant - CHU de Grenoble, Grenoble, France

Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine

Phase 4

Completed

Conditions: Coronary Artery Disease

Interventions: Other: Placebo
Drug: Methylnaltrexone
Drug: Morphine
Drug: Ticagrelor

First Posted Date: 2015-03-31

Last Posted Date: 2017-05-30

Lead Sponsor: University of Florida

Target Recruit Count: 30

Registration Number: NCT02403830

Locations: 🇺🇸
University of Florida, Jacksonville, Florida, United States

is There an Alternative to Ultrasound Guided Interscalene Block?

Not Applicable

Conditions: Shoulder Surgery
Regional Anesthesia
Interscalene Block

Interventions: Drug: bupivacaine
Device: ultrasound
Drug: morphine

First Posted Date: 2015-03-24

Last Posted Date: 2015-03-24

Lead Sponsor: Tunisian Military Hospital

Target Recruit Count: 60

Registration Number: NCT02397330

Ultrasound Guided Femoral Nerve Block

Not Applicable

Recruiting

Conditions: Hip Fracture

Interventions: Other: ultra-sound guide
Drug: morphine
Drug: bupivacaine

First Posted Date: 2015-03-06

Last Posted Date: 2024-04-03

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 60

Registration Number: NCT02381717

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸
St. Vincent's Hospital, Worcester, Massachusetts, United States

The Effects of Morphine on Desflurane Consumption and Recovery Time

Phase 4

Completed

Conditions: Abdominal Hysterectomy (& Wertheim)

Interventions: Drug: Morphine

First Posted Date: 2015-02-12

Last Posted Date: 2015-12-03

Lead Sponsor: Baskent University

Target Recruit Count: 90

Registration Number: NCT02362022

Locations: 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey

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