Morphine

Generic Name
Morphine
Brand Names
Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
Drug Type
Small Molecule
Chemical Formula
C17H19NO3
CAS Number
57-27-2
Unique Ingredient Identifier
76I7G6D29C
Background

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorp...

Indication

Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions
Chronic Pain, Severe Pain
Associated Therapies
-
Clinical Trials
Related News

Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine

Phase 4
Terminated
Conditions
Pain, Postoperative
Osteoarthritis
First Posted Date
2005-12-26
Last Posted Date
2007-04-11
Lead Sponsor
Rambam Health Care Campus
Target Recruit Count
80
Registration Number
NCT00270322
Locations
🇮🇱

Rambam Health Care Campus, Haifa, Israel

Opiate-Induced Tolerance & Hyperalgesia in Pain Patients

First Posted Date
2005-10-30
Last Posted Date
2012-04-30
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Target Recruit Count
139
Registration Number
NCT00246532
Locations
🇺🇸

Stanford University School of Medicine, Stanford, California, United States

Pre-hospital Morphine Titration : Comparison of 0,05 Versus 0,1 mg/kg

Phase 4
Completed
Conditions
Severe, Acute Pain in a Pre-hospital Setting
Interventions
Drug: morphine
First Posted Date
2005-10-12
Last Posted Date
2017-05-12
Lead Sponsor
University Hospital, Toulouse
Target Recruit Count
106
Registration Number
NCT00237731
Locations
🇫🇷

SAMU 31 Hôpital PURPAN, Toulouse, France

Safety and Efficacy Study of Hydromorphone and Morphine

Phase 2
Completed
Conditions
Pain
Interventions
Drug: Morphine
Drug: Hydromorphone
First Posted Date
2005-09-20
Last Posted Date
2018-08-15
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
198
Registration Number
NCT00195910
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Problems With Morphine Use in Patients With a Severe Brain Injury

First Posted Date
2005-09-20
Last Posted Date
2008-04-10
Lead Sponsor
Dalhousie University
Target Recruit Count
20
Registration Number
NCT00196131
Locations
🇨🇦

Capital Health -QE II HSC, Halifax, Nova Scotia, Canada

Opioid Receptors Influence Ischemia-Reperfusion Injury

Not Applicable
Suspended
Conditions
Ischemia-Reperfusion Injury
First Posted Date
2005-09-16
Last Posted Date
2008-03-28
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
40
Registration Number
NCT00184938
Locations
🇳🇱

Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology, Nijmegen, Gelderland, Netherlands

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Phase 4
Completed
Conditions
Sedation
First Posted Date
2005-09-12
Last Posted Date
2008-10-16
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
224
Registration Number
NCT00158873
Locations
🇳🇱

GSK Investigational Site, Zwolle, Netherlands

Tramadol to Reduce Opioid Withdrawal Symptoms

Phase 2
Completed
Conditions
Opioid-Related Disorders
First Posted Date
2005-09-02
Last Posted Date
2017-01-12
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Target Recruit Count
16
Registration Number
NCT00142896
Locations
🇺🇸

Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, United States

Bioavailability and Effectiveness of Transdermally Administered Morphine

Phase 1
Completed
Conditions
Cancer
Pain
First Posted Date
2005-08-02
Last Posted Date
2012-01-19
Lead Sponsor
Alberta Health services
Target Recruit Count
6
Registration Number
NCT00125684
Locations
🇨🇦

Tom Baker Cancer Centre, Calgary, Alberta, Canada

Morphine for the Treatment of Pain in Patients With Breast Cancer

Completed
Conditions
Pain
First Posted Date
2004-07-30
Last Posted Date
2015-10-14
Lead Sponsor
Roswell Park Cancer Institute
Target Recruit Count
18
Registration Number
NCT00003000
Locations
🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

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