代他考昔 (Bextra)

概览

Valdecoxib is a COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea.

作用机制

Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane. Valdecoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, important for the mediation of inflammation and pain. Unlike non-selective NSAIDs, valdecoxib does not inhibit platelet aggregation.

适应症

For the treatment of osteoarthritis and dysmenorrhoea

• Osteoarthritis (OA)
• Primary Dysmenorrhoea
• Rheumatoid Arthritis