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Research Report
Allogeneic CD22-Directed CAR T Cell Therapy (SC262) by Sana Biotechnology: A Comprehensive Overview
I. Introduction
Chimeric Antigen Receptor (CAR) T cell therapy represents a significant advancement in cancer treatment, particularly for hematological malignancies. Autologous CAR T therapies, which utilize a patient's own T cells engineered to target cancer antigens like CD19, have demonstrated remarkable efficacy in B-cell cancers.[1] However, the widespread application of autologous CAR T faces considerable challenges, including complex and lengthy patient-specific manufacturing processes, potential for manufacturing failures due to poor patient T cell quality, and treatment delays that can be critical for patients with aggressive disease.[1]
Allogeneic, or "off-the-shelf," CAR T therapies derived from healthy donors offer potential solutions to these limitations, promising immediate availability, manufacturing scalability, and product consistency.[1] Despite these advantages, the development of allogeneic CAR T cells has been significantly hampered by fundamental immunological barriers. The recipient's immune system readily recognizes donor T cells as foreign, leading to their rapid rejection (host-versus-graft rejection), which curtails therapeutic persistence and efficacy.[1] Conversely, the infused donor T cells can attack the recipient's healthy tissues, causing potentially fatal graft-versus-host disease (GvHD).[1] Current strategies to mitigate these issues often rely on intensive patient immunosuppression, which introduces substantial risks of infection and other complications.[3]
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/02/29 | Phase 1 | Recruiting |
FDA Drug Approvals
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EMA Drug Approvals
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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TGA Drug Approvals
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Health Canada Drug Approvals
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| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
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| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
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| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
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| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
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| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
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