Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060)

Phase 3

Terminated

Conditions: Dysmenorrhea

Interventions: Drug: ENG 125 μg + E2 300 μg vaginal ring (MK-8342B)
Drug: Placebo vaginal ring
Drug: Ibuprofen

First Posted Date: 2016-01-29

Last Posted Date: 2024-05-28

Lead Sponsor: Organon and Co

Target Recruit Count: 18

Registration Number: NCT02668822

Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059)

Phase 3

Terminated

Conditions: Moderate to Severe Primary Dysmenorrhea

Interventions: Drug: Etonogestrel (ENG) 125 μg + 17β-estradiol (E2) 300 μg vaginal ring
Drug: Placebo vaginal ring
Drug: Ibuprofen

First Posted Date: 2016-01-29

Last Posted Date: 2024-05-28

Lead Sponsor: Organon and Co

Target Recruit Count: 25

Registration Number: NCT02668783

Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model

Phase 1

Completed

Conditions: Pain

Interventions: Drug: Placebo
Drug: Methyl-salicylate / Menthol
Drug: Diclofenac
Drug: Ibuprofen

First Posted Date: 2016-01-28

Last Posted Date: 2021-01-27

Lead Sponsor: Futura Medical Developments Ltd.

Target Recruit Count: 60

Registration Number: NCT02666846

Locations: 🇬🇧
PAREXEL EPCU Northwick Park, Harrow, Middlesex, United Kingdom

Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular Torticollis

Phase 4

Completed

Conditions: Congenital Muscular Torticollis

Interventions: Other: intermediate cervical plexus block
Drug: Fentanyl
Drug: Ibuprofen

First Posted Date: 2016-01-11

Last Posted Date: 2017-01-27

Lead Sponsor: Ajou University School of Medicine

Target Recruit Count: 32

Registration Number: NCT02651311

Locations: 🇰🇷
Ajou University School of Medicine, Suwon, Gyeong-gi, Korea, Republic of

To Determine Blood Concentrations of Ibuprofen and Caffeine in a Tablet Against Ibuprofen Alone From Another Tablet

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Ibuprofen
Drug: Caffeine

First Posted Date: 2015-12-14

Last Posted Date: 2017-05-05

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 36

Registration Number: NCT02629354

Locations: 🇿🇦
Boehringer Ingelheim Investigational Site, Bloemfontein, South Africa

Patient-Driven Analgesic Protocol Selection for Post-Cesarean Pain Management

Not Applicable

Completed

Conditions: Postoperative Pain

Interventions: Other: Choice given
Other: No choice given
Drug: Ibuprofen
Drug: Acetaminophen
Drug: Morphine (med)
Drug: Morphine (low)
Drug: Gabapentin
Drug: Morphine (high)

First Posted Date: 2015-11-16

Last Posted Date: 2018-10-16

Lead Sponsor: Stanford University

Target Recruit Count: 160

Registration Number: NCT02605187

Locations: 🇺🇸
Lucille Packard Children's Hospital, Palo Alto, California, United States

Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery

Not Applicable

Recruiting

Conditions: Inguinal Surgery

Interventions: Drug: Ibuprofen
Drug: Morphine

First Posted Date: 2015-11-13

Last Posted Date: 2023-03-15

Lead Sponsor: McMaster University

Target Recruit Count: 100

Registration Number: NCT02603848

Locations: 🇨🇦
McMaster Children's Hospital, Hamilton, Ontario, Canada

Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).

Phase 1

Completed

Conditions: Temporomandibular Joint Disorders

Interventions: Drug: Magnesium
Drug: Ibuprofen
Drug: Placebo
Drug: Ascorbic Acid

First Posted Date: 2015-11-11

Last Posted Date: 2017-01-19

Lead Sponsor: Spherium Biomed

Target Recruit Count: 96

Registration Number: NCT02602483

Locations: 🇪🇸
Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain
🇪🇸
Clinica Universitaria Odontològica de la Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain
🇪🇸
Hospital Odontològic de la Universitat de Barcelona, Barcelona, Spain

and more 1 locations