Ibuprofen

Generic Name
Ibuprofen
Brand Names
Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph
Drug Type
Small Molecule
Chemical Formula
C13H18O2
CAS Number
15687-27-1
Unique Ingredient Identifier
WK2XYI10QM
Background

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication

Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions
Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain
Associated Therapies
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Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production

First Posted Date
2009-06-16
Last Posted Date
2011-07-06
Lead Sponsor
Ullevaal University Hospital
Target Recruit Count
7
Registration Number
NCT00921505
Locations
🇳🇴

Ullevaal University Hospital, Oslo, Norway

Study Evaluating Ibuprofen 600 mg Extended Release (ER) For Dental Pain

Phase 2
Completed
Conditions
Interventions
First Posted Date
2009-06-04
Last Posted Date
2018-03-22
Lead Sponsor
Pfizer
Target Recruit Count
196
Registration Number
NCT00913627
Locations
🇺🇸

Jean Brown Research Center, Salt Lake City, Utah, United States

Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery

First Posted Date
2009-05-08
Last Posted Date
2009-06-01
Lead Sponsor
University of Manchester
Target Recruit Count
122
Registration Number
NCT00895843
Locations
🇬🇧

Central Manchester and Manchester Children's NHS University Hospitals, Manchester, Lancashire, United Kingdom

🇬🇧

Central Manchester NHS Foundation Trust, Manchester, Lancashire, United Kingdom

Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever

First Posted Date
2009-04-30
Last Posted Date
2024-01-30
Lead Sponsor
University of Washington
Target Recruit Count
10
Registration Number
NCT00890604
Locations
🇺🇸

Harborview Medical Center, Seattle, Washington, United States

Ibuprofen and Opioid (Morphine or Diamorphine) for Acute Pain in Sickle Cell Disease - Sickle With Ibuprofen & Morphine

First Posted Date
2009-04-13
Last Posted Date
2012-12-04
Lead Sponsor
London North West Healthcare NHS Trust
Target Recruit Count
320
Registration Number
NCT00880373
Locations
🇬🇧

North West London Hospitals NHS Trust, London, United Kingdom

🇬🇧

Imperial College Healthcare NHS Trust, London, United Kingdom

Etoricoxib Versus Ibuprofen in Third Molar Extraction Pain

First Posted Date
2009-03-04
Last Posted Date
2009-03-04
Lead Sponsor
Universita di Verona
Target Recruit Count
110
Registration Number
NCT00855777

Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure

Not Applicable
Terminated
Conditions
Interventions
First Posted Date
2009-02-02
Last Posted Date
2016-07-04
Lead Sponsor
University of Utah
Target Recruit Count
15
Registration Number
NCT00833365
Locations
🇺🇸

University of Utah, Salt Lake City, Utah, United States

Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

First Posted Date
2009-01-30
Last Posted Date
2009-01-30
Lead Sponsor
Bispebjerg Hospital
Target Recruit Count
36
Registration Number
NCT00833157

The Efficacy and Safety of Dexibuprofen Syrup

First Posted Date
2008-12-22
Last Posted Date
2010-01-18
Lead Sponsor
Inje University
Target Recruit Count
260
Registration Number
NCT00812422
Locations
🇰🇷

Inje University Sanggye Paik Hospital, Seoul, Korea, Republic of

🇰🇷

Asan Medical Center, Seoul, Korea, Republic of

🇰🇷

Kyung Hee University Hospital, Seoul, Korea, Republic of

and more 1 locations

The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen in Knee Osteoarthritis

First Posted Date
2008-11-18
Last Posted Date
2012-10-30
Lead Sponsor
Mahidol University
Target Recruit Count
367
Registration Number
NCT00792818
Locations
🇹🇭

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

🇹🇭

VachiraPhuket Hospital, Phuket, Thailand

🇹🇭

Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

and more 3 locations
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