Apatorsen

Overview

Apatorsen is a second generation antisense drug which in preclinical experiments, inhibits production of Heat Shock Protein 27 (Hsp27) a cell survival protein found at elevated levels in many human cancers including prostate, lung, breast, ovarian, bladder, renal, pancreatic, multiple myeloma and liver cancer.

Indication

Investigated for use/treatment in cancer/tumors (unspecified).

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Study of Gemcitabine/Carboplatin First-line Chemotherapy +/- Apatorsen in Advanced Squamous Cell Lung Cancers	2015/04/22	NCT02423590	Phase 2	UNKNOWN	Queen Mary University of London
Phase II Trial Of Gemcitabine Plus Nab-Paclitaxel +/- OGX-427 In Patients With Metastatic Pancreatic Cancer	2013/05/01	NCT01844817	Phase 2	Completed	SCRI Development Innovations, LLC
Phase II Trial of Carboplatin and Pemetrexed +/- OGX-427 in Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer	2013/04/11	NCT01829113	Phase 2	Completed	SCRI Development Innovations, LLC
Phase 2 Study of Docetaxel +/- OGX-427 in Patients With Relapsed or Refractory Metastatic Bladder Cancer	2013/01/31	NCT01780545	Phase 2	Completed	Noah Hahn, M.D.
OGX-427 in Metastatic Castrate-Resistant Prostate Cancer With Prostate-Specific Antigen Progression While Receiving Abiraterone	2012/09/10	NCT01681433	Phase 2	Terminated	Costantine Albany
OGX-427 in Castration Resistant Prostate Cancer Patients	2010/05/11	NCT01120470	Phase 2	Completed	British Columbia Cancer Agency
A Study for Treatment of Superficial Bladder Cancer Using OGX-427	2009/08/17	NCT00959868	Phase 1	UNKNOWN	Vancouver Coastal Health
Safety Study of an Antisense Product in Prostate, Ovarian, NSCL, Breast or Bladder Cancer	2007/06/19	NCT00487786	Phase 1	Completed	Achieve Life Sciences

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

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