Phenytoin
- Generic Name
- Phenytoin
- Brand Names
- Dilantin, Phenytek
- Drug Type
- Small Molecule
- Chemical Formula
- C15H12N2O2
- CAS Number
- 57-41-0
- Unique Ingredient Identifier
- 6158TKW0C5
- Background
Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina protection, and wound healing.
Clinicians are advised to initiate therapeutic drug monitoring in patients who require phenytoin since even small deviations from the recommended therapeutic range can lead to suboptimal treatment, or adverse effects. Both parenteral and oral formulations of phenytoin are available on the market.
- Indication
Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. Injectable phenytoin and Fosphenytoin, which is the phosphate ester prodrug formulation of phenytoin, are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurring during neurosurgery.
- Associated Conditions
- Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Grand Mal Status Epilepticus, Jacksonian epilepsy, Partial-Onset Seizures, Petit Mal Epilepsy, Seizure Disorder, Post Traumatic, Seizures, Status; Epilepticus, Tonic-clonic, Temporal Lobe Epilepsy (TLE), Convulsive disorders
Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29)
- Conditions
- Healthy Participants
- Interventions
- First Posted Date
- 2025-04-09
- Last Posted Date
- 2025-05-18
- Lead Sponsor
- Arcus Biosciences, Inc.
- Target Recruit Count
- 14
- Registration Number
- NCT06919991
- Locations
- 🇺🇸
Celerion, Tempe, Arizona, United States
Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants
- Conditions
- Healthy Volunteers
- Interventions
- First Posted Date
- 2025-04-02
- Last Posted Date
- 2025-05-01
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 30
- Registration Number
- NCT06906809
- Locations
- 🇺🇸
Fortrea Clinical Research Unit Inc, Madison, Wisconsin, United States
A Clinical Study of Belzutifan (MK-6482) Alone or With Phenytoin in Healthy Participants (CA46602/MK-6482-035)
- First Posted Date
- 2025-04-01
- Last Posted Date
- 2025-05-01
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 14
- Registration Number
- NCT06903715
- Locations
- 🇺🇸
Celerion, Inc. ( Site 0001), Tempe, Arizona, United States
A Study of the Effect of Itraconazole and Phenytoin on MK-1084 in Healthy Adults (MK-1084-008)
- First Posted Date
- 2024-12-06
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 28
- Registration Number
- NCT06719557
- Locations
- 🇺🇸
Celerion (Site 0001), Lincoln, Nebraska, United States
Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery.
- Conditions
- Anal Fissure ChronicAnal FissureWound Healing
- Interventions
- First Posted Date
- 2024-10-09
- Last Posted Date
- 2024-10-09
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 50
- Registration Number
- NCT06633185
- Locations
- 🇪🇬
Mansoura university, Mansoura, Dakahlia, Egypt
A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers
- Conditions
- Not Determined
- Interventions
- First Posted Date
- 2024-08-07
- Last Posted Date
- 2024-11-27
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 30
- Registration Number
- NCT06543043
- Locations
- 🇺🇸
Quotient Sciences, Miami, Florida, United States
A Study to Learn How Different Forms of The Study Medicine Called Phenytoin Are Taken up Into the Blood in Healthy Adults
- First Posted Date
- 2024-06-20
- Last Posted Date
- 2024-10-08
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 35
- Registration Number
- NCT06466473
- Locations
- 🇺🇸
Pfizer Clinical Research Unit - New Haven, New Haven, Connecticut, United States
Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects
- Conditions
- Pharmacokinetics
- Interventions
- First Posted Date
- 2024-04-23
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Modern Biosciences Ltd
- Target Recruit Count
- 48
- Registration Number
- NCT06379958
- Locations
- 🇬🇧
Celerion, Belfast, United Kingdom
Pharmacological Modulation of Peripheral Nerve Excitability
- Conditions
- Peripheral Neuropathy
- Interventions
- Other: Topical Placebo
- First Posted Date
- 2024-03-15
- Last Posted Date
- 2025-04-30
- Lead Sponsor
- Aalborg University
- Target Recruit Count
- 20
- Registration Number
- NCT06312254
- Locations
- 🇩🇰
Center for Neuroplasticity and Pain, Aalborg, Denmark
Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad
- First Posted Date
- 2023-10-04
- Last Posted Date
- 2023-10-04
- Lead Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
- Target Recruit Count
- 70
- Registration Number
- NCT06067412
- Locations
- 🇵🇰
Children Hopsital Faisalabad, Faisalābad, Punjab, Pakistan
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.