Phenytoin

Generic Name
Phenytoin
Brand Names
Dilantin, Phenytek
Drug Type
Small Molecule
Chemical Formula
C15H12N2O2
CAS Number
57-41-0
Unique Ingredient Identifier
6158TKW0C5
Background

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as bipolar disorder, retina prote...

Indication

Phenytoin is indicated to treat grand mal seizures, complex partial seizures, and to prevent and treat seizures during or following neurosurgery. Injectable phenytoin and Fosphenytoin, which is the phosphate ester prodrug formulation of phenytoin, are indicated to treat tonic-clonic status epilepticus, and for the prevention and treatment of seizures occurri...

Associated Conditions
Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Grand Mal Status Epilepticus, Jacksonian epilepsy, Partial-Onset Seizures, Petit Mal Epilepsy, Seizure Disorder, Post Traumatic, Seizures, Status; Epilepticus, Tonic-clonic, Temporal Lobe Epilepsy (TLE), Convulsive disorders
Associated Therapies
-
Clinical Trials
Related News

Pharmacokinetics of Antiepileptics in Patients on CRRT

First Posted Date
2018-08-16
Last Posted Date
2021-10-05
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
18
Registration Number
NCT03632915
Locations
🇺🇸

University of Maryland Medical Center, Baltimore, Maryland, United States

Population Pharmacokinetics of Antiepileptic in Pediatrics

First Posted Date
2017-06-22
Last Posted Date
2024-10-30
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
1000
Registration Number
NCT03196466
Locations
🇫🇷

AP-HP Cochin, Paris, France

Effect of Phenytoin on the Ganglion Cell Layer in Patients With Optic Neuritis

Phase 2
Completed
Conditions
Optic Neuritis
Interventions
Drug: placebo
Drug: Phenytoin
First Posted Date
2016-10-20
Last Posted Date
2019-08-12
Lead Sponsor
Tehran University of Medical Sciences
Target Recruit Count
71
Registration Number
NCT02939937
Locations
🇮🇷

Eye Research Center Farabi Hosoital, Tehran, Iran, Islamic Republic of

Phenytoin in the Healing of Clean Surgical Wounds

First Posted Date
2015-04-10
Last Posted Date
2015-04-10
Lead Sponsor
Children's Surgical Center, Cambodia
Target Recruit Count
100
Registration Number
NCT02413658
Locations
🇰🇭

Children's Surgical Centre, Phnom Penh, Cambodia

Comparative Trial of IV Lacosamide Versus Phenytoin for Seizure Management

Phase 4
Terminated
Conditions
Seizures
Interventions
Drug: lacosamide
Drug: Phenytoin
First Posted Date
2015-04-06
Last Posted Date
2016-01-07
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
3
Registration Number
NCT02409433
Locations
🇨🇦

University Hospital, London, Ontario, Canada

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Open-label Drug Interaction Study Between Eslicarbazepine Acetate and Phenytoin.

Phase 1
Completed
Conditions
Epilepsy
Interventions
Drug: BIA 2-093
Drug: Phenytoin
First Posted Date
2014-11-05
Last Posted Date
2014-12-18
Lead Sponsor
Bial - Portela C S.A.
Target Recruit Count
32
Registration Number
NCT02283827

The Effect of BIA 2-093 on the Steady-state Pharmacokinetic Profile of Phenytoin in Patients

First Posted Date
2013-06-17
Last Posted Date
2014-02-27
Lead Sponsor
Bial - Portela C S.A.
Target Recruit Count
4
Registration Number
NCT01878578
Locations
🇵🇹

Neurology Department, Hospital of Santa Maria, Lisbon, Portugal

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

First Posted Date
2012-11-21
Last Posted Date
2022-05-18
Lead Sponsor
Centers for Disease Control and Prevention
Registration Number
NCT01730313
Locations
🇺🇬

Kitgum Nodding Syndrome Treatment Center, Kitgum General Hospital, Kitgum, Uganda

A Study to Investigate the Potential Pharmacokinetic Interactions Between Phenytoin or Carbamazepine and Telaprevir

First Posted Date
2012-07-10
Last Posted Date
2013-10-24
Lead Sponsor
Janssen Infectious Diseases BVBA
Target Recruit Count
24
Registration Number
NCT01635829
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