MedPath

Marstacimab

Generic Name
Marstacimab
Drug Type
Biotech
CAS Number
1985638-39-8
Unique Ingredient Identifier
0UB3OA67O7
Background

Marstacimab is a human Monoclonal Antibody Directed Against Tissue Factor Pathway Inhibitor currently being developed by Pfizer for the treatment of hemophilia A and hemophilia B.

A Study to Learn About How Changing Therapy From Emicizumab to Marstacimab Affects People With the Severe Hemophilia A.

Phase 1
Not yet recruiting
Conditions
Severe Hemophilia A
Interventions
First Posted Date
2024-11-25
Last Posted Date
2025-01-24
Lead Sponsor
Pfizer
Target Recruit Count
10
Registration Number
NCT06703606

A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B

Phase 3
Recruiting
Conditions
Hemophilia A
Hemophilia B
Interventions
First Posted Date
2022-11-10
Last Posted Date
2024-12-24
Lead Sponsor
Pfizer
Target Recruit Count
100
Registration Number
NCT05611801
Locations
🇺🇸

Intermountain - Primary Children's Hospital, Salt Lake City, Utah, United States

🇦🇷

Arbesu Hematología, Mendoza, Argentina

🇦🇺

Sydney Children's Hospital, Randwick, New South Wales, Australia

and more 61 locations

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors

Phase 3
Recruiting
Conditions
Hemophilia A
Hemophilia B
Interventions
First Posted Date
2021-12-06
Last Posted Date
2024-12-24
Lead Sponsor
Pfizer
Target Recruit Count
245
Registration Number
NCT05145127
Locations
🇺🇸

University of Iowa, Iowa City, Iowa, United States

🇺🇸

Northwell Health HTC, New Hyde Park, New York, United States

🇺🇸

Washington Institute for Coagulation d/b/a WACBD, Seattle, Washington, United States

and more 49 locations

A Study of Marstacimab to Compare Prefilled Pen (PFP) Device to Prefilled Syringe (PFS) Device

Phase 1
Terminated
Conditions
Healthy Volunteers
Interventions
First Posted Date
2021-04-05
Last Posted Date
2022-07-11
Lead Sponsor
Pfizer
Target Recruit Count
22
Registration Number
NCT04832139
Locations
🇧🇪

Brussels Clinical Research Unit, Brussels, Bruxelles-capitale, Région DE, Belgium

Study of the Efficacy and Safety PF-06741086 in Adult and Teenage Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B

Phase 3
Active, not recruiting
Conditions
Hemophilia B
Hemophilia A
Interventions
First Posted Date
2019-05-06
Last Posted Date
2024-10-10
Lead Sponsor
Pfizer
Target Recruit Count
186
Registration Number
NCT03938792
Locations
🇺🇸

Washington Institute for Coagulation, Seattle, Washington, United States

🇨🇳

Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, Tianjin, China

🇺🇸

USF Health Morsani Center For Advanced Healthcare, Tampa, Florida, United States

and more 61 locations
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