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D-0120

Generic Name
D-0120

Hyperuricemia Pipeline Shows Promise with 15+ Emerging Therapies in Development

• Global hyperuricemia pipeline comprises 12+ key companies developing 15+ treatment therapies across various clinical stages, according to DelveInsight's 2025 report. • Leading companies in hyperuricemia drug development include LG Chem, Shanton Pharma, InventisBio, Jiangsu HengRui Medicine, and Selecta Biosciences, with treatments spanning oral, intravenous, and subcutaneous administration routes. • A significant development occurred in December 2024 when Atom Therapeutics partnered with China Medical System Holdings to commercialize lingdolinurad (ABP-671), a novel URAT1 inhibitor for chronic gout and hyperuricemia in China.

Gout Pipeline Shows Promise with Novel Therapies in Clinical Development

• A new report highlights over 30 drugs in the gout pipeline, showcasing potential advancements in treatment strategies and offering hope for patients with this debilitating condition. • LG Chem's Tigulixostat, a novel xanthine oxidase inhibitor, is in Phase III trials as a potential first-line treatment for gout, demonstrating efficacy in lowering serum uric acid levels. • Shanton Pharma's SAP-001, a urate transporter inhibitor, is in Phase II development targeting refractory and tophaceous gout, addressing the needs of patients unresponsive to standard therapies. • InventisBio's D-0120, a selective URAT1 inhibitor, shows promise in Phase II trials with a potentially more potent uric acid-lowering effect and improved safety profile compared to existing treatments.
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