Camostat
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Camostat is a serine protease indicated in Japan to treat chronic pancreatitis.
Camostat is a serine protease indicated in Japan to treat chronic pancreatitis.
In rats, oral camostat mesylate may increase pancreatic secretions and hypertrophy by increasing cholecystokinin release. Administration in rats has also lead to lower levels of IL-1beta, IL-6, TNF-alpha, TGF-beta, and PSC. Similar activity is seem after administration in humans, leading to reduced pain and inflammation as well as improve the function of the pancrease in chronic pancreatitis. In the case of SARS-CoV-2, camostat mesylate inhibits the action of the serine protease TMPRSS2, preventing the priming of the viral spike protein for attachment to ACE2, and entry into the cell.
用于慢性胰腺炎的急性症状缓解。
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
