双氯青霉素

概览

Dicloxacillin is a penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug.

作用机制

Dicloxacillin exerts a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, dicloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that dicloxacillin interferes with an autolysin inhibitor.

适应症

Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.

• Infections caused by penicillinase-producing staphylococci