Tacrolimus
- Generic Name
- Tacrolimus
- Brand Names
- Advagraf, Astagraf, Envarsus, Modigraf, Prograf, Protopic, Tacforius
- Drug Type
- Small Molecule
- Chemical Formula
- C44H69NO12
- CAS Number
- 104987-11-3
- Unique Ingredient Identifier
- Y5L2157C4J
- Background
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condi...
- Indication
Immediate-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants, in combination with other immunosuppressants. Extended-release formulations of tacrolimus are indicated for the prophylaxis of organ rejection in adult and pediatric ...
- Associated Conditions
- Graft-versus-host Disease (GVHD), Heart Transplant Rejection, Kidney Transplant Rejection, Liver Transplant Rejection, Lung Transplant Rejection, Oral Lichen Planus, Psoriasis, Pyoderma Gangrenosum, Rheumatoid Arthritis, Severe Atopic Dermatitis, Vitiligo, Moderate Atopic dermatitis
- Associated Therapies
- -
Effectiveness and Cost-effectiveness of a Pre-emptive Genotyping Strategy in Patients Receiving Tacrolimus
- Conditions
- Interventions
- First Posted Date
- 2024-11-22
- Last Posted Date
- 2024-12-03
- Target Recruit Count
- 160
- Registration Number
- NCT06701825
- Locations
- 🇪🇸
Hospital La Paz, Madrid, Comunidad De Madrid, Spain
Ph I Trial of Cell Based Therapy for DMD
- Conditions
- Interventions
- First Posted Date
- 2024-11-18
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Target Recruit Count
- 8
- Registration Number
- NCT06692426
ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis
- Conditions
- Interventions
- First Posted Date
- 2024-11-08
- Last Posted Date
- 2024-11-08
- Lead Sponsor
- Leland Metheny
- Target Recruit Count
- 20
- Registration Number
- NCT06680661
- Locations
- 🇺🇸
University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Tacrolimus Toothpaste for Management of Oral Chronic Graft vs. Host Disease (cGVHD)
- First Posted Date
- 2024-10-15
- Last Posted Date
- 2024-11-12
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Target Recruit Count
- 13
- Registration Number
- NCT06638879
- Locations
- 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Utilising Genotype Informed Bayesian Dosing of Tacrolimus in Children Post Solid Organ Transplantation.
- Conditions
- Interventions
- First Posted Date
- 2024-07-31
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Murdoch Childrens Research Institute
- Target Recruit Count
- 45
- Registration Number
- NCT06529536
- Locations
- 🇦🇺
Royal Children's Hospital, Melbourne, Victoria, Australia
Belatacept in Heart Transplantation
- Conditions
- Interventions
- First Posted Date
- 2024-06-27
- Last Posted Date
- 2024-10-31
- Target Recruit Count
- 66
- Registration Number
- NCT06478017
- Locations
- 🇺🇸
Cedars Sinai Heart Institute/ Cedars Sinai Medical (Site # 71146), Los Angeles, California, United States
🇺🇸Tampa General Hospital (Site # 71150), Tampa, Florida, United States
🇺🇸NYU Langone Health (Site # 71177), New York, New York, United States
MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.
- Conditions
- Interventions
- First Posted Date
- 2024-05-14
- Last Posted Date
- 2024-06-10
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Target Recruit Count
- 60
- Registration Number
- NCT06412497
- Locations
- 🇺🇸
University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, United States
High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-11-05
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT06345495
- Locations
- 🇺🇸
MD Anderson Cancer Center, Houston, Texas, United States
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
- Conditions
- Interventions
- First Posted Date
- 2024-03-13
- Last Posted Date
- 2024-03-13
- Lead Sponsor
- University Hospital, Grenoble
- Target Recruit Count
- 66
- Registration Number
- NCT06307808
- Locations
- 🇫🇷
Grenoble University Hospital, Grenoble, Aura, France
Topical Tacrolimus for Breast Cancer-related Lymphedema
- First Posted Date
- 2024-03-12
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Odense University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT06306274
- Locations
- 🇩🇰
Odense University Hospital, Odense, Denmark
🇩🇰Zealand University Hospital, Roskilde, Denmark
🇩🇰Lillebaelt Hospital, Vejle, Denmark
Drug Development Updates
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