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LB-100

Generic Name
LB-100
Drug Type
Small Molecule
Chemical Formula
C13H20N2O4
CAS Number
1632032-53-1
Unique Ingredient Identifier
0C1JUU9S0L
Background

LB-100 is under investigation in clinical trial NCT03886662 (A Study of LB-100 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)).

Clinical Trials
Related News

Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100

Phase 1
Recruiting
Conditions
Ovarian Clear Cell Carcinoma
Interventions
First Posted Date
2023-10-04
Last Posted Date
2025-05-18
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
21
Registration Number
NCT06065462
Locations
🇺🇸

M D Anderson Cancer Center, Houston, Texas, United States

LB-100 (PP2A Inhibitor) and Atezolizumab (PD-L1 Inhibitor) in Metastatic Colorectal Cancer Patients

Phase 1
Not yet recruiting
Conditions
Metastatic Microsatellite-stable Colorectal Cancer
Interventions
First Posted Date
2023-08-25
Last Posted Date
2023-09-05
Lead Sponsor
The Netherlands Cancer Institute
Target Recruit Count
37
Registration Number
NCT06012734
Locations
🇳🇱

Antoni van Leeuwenhoek, Amsterdam, Noord Holland, Netherlands

Phase I/II of LB-100 Plus Doxorubicin Vs. Doxorubicin Alone in First Line of Advanced Soft Tissue Sarcomas

Phase 1
Active, not recruiting
Conditions
Advanced Soft-tissue Sarcoma
Interventions
First Posted Date
2023-04-12
Last Posted Date
2025-03-21
Lead Sponsor
Grupo Espanol de Investigacion en Sarcomas
Target Recruit Count
152
Registration Number
NCT05809830
Locations
🇪🇸

Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña, Spain

🇪🇸

Hospital Clínico Universitario de Valencia, Valencia, Comunidad Valenciana, Spain

🇪🇸

Hospital Clínico San Carlos, Madrid, Spain

and more 3 locations

A Study of LB-100 in Patients With Low or Intermediate-1 Risk Myelodysplastic Syndromes (MDS)

Phase 1
Recruiting
Conditions
Myelodysplastic Syndromes
Interventions
First Posted Date
2019-03-22
Last Posted Date
2019-04-08
Lead Sponsor
Lixte Biotechnology Holdings, Inc.
Target Recruit Count
47
Registration Number
NCT03886662
Locations
🇺🇸

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, United States

Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Phase 2
Completed
Conditions
Oligodendrogliomas
Astrocytoma, Grades II, III and IV
Glioblastoma Multiforme
Giant Cell Glioblastoma
Glioma
Interventions
First Posted Date
2017-01-23
Last Posted Date
2023-11-22
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
7
Registration Number
NCT03027388
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Phase I Study of LB-100 With Docetaxel in Solid Tumors

Phase 1
Completed
Conditions
Neoplasms
Tumors
Cancer
Interventions
First Posted Date
2013-04-23
Last Posted Date
2017-01-24
Lead Sponsor
Lixte Biotechnology Holdings, Inc.
Target Recruit Count
29
Registration Number
NCT01837667
Locations
🇺🇸

Texas Oncology - Tyler, Tyler, Texas, United States

🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

🇺🇸

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

and more 2 locations
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