A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. The agent has also been indicated for treating panic disorder. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.
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Clonazepam is indicated as monotherapy or as an adjunct in the treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. Furthermore, clonazepam may also be of some value in patients with absence spells (petit mal) who have failed to respond to succinimides. Additionally, clonazepam is also indicated for the treatment of pan...
Bezirkskrankenhaus Augsburg, Augsburg, Germany
Krankenhaus Hedwigshöhe, Berlin, Germany
Hannover Medical School, Hannover, Germany
Seoul National University Hospital, Seoul, Korea, Republic of
Cooper Universtiy Hospital, Camden, New Jersey, United States
Département d'Anesthésie - Réanimation - SMUR - Hôpital Lariboisière, Paris, France
University Hospitals, Geneva, Switzerland
Dep of Anesthesiology and Pain Therapy, University Hospital Bern, Bern, Switzerland
Pfizer Investigational Site, Col. Arenal Tepepan, Mexico D.F., Mexico
Clinical Trials. inc., Little Rock, Arkansas, United States
Ohio State University, Columbus, Ohio, United States
Columbia Comprehensive Epilepsy Center, Neurological Institute, New York, New York, United States
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