Clonazepam

Generic Name
Clonazepam
Brand Names
Clonapam, Klonopin, Rivotril
Drug Type
Small Molecule
Chemical Formula
C15H10ClN3O3
CAS Number
1622-61-3
Unique Ingredient Identifier
5PE9FDE8GB
Background

A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. The agent has also been indicated for treating panic disorder. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.
...

Indication

Clonazepam is indicated as monotherapy or as an adjunct in the treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. Furthermore, clonazepam may also be of some value in patients with absence spells (petit mal) who have failed to respond to succinimides. Additionally, clonazepam is also indicated for the treatment of pan...

Associated Conditions
Akinetic seizures, Burning Mouth Syndrome, Essential Tremor, Gilles de la Tourette's Syndrome, Lennox-Gastaut Syndrome, Mixed manic depressive episode, Panic Disorder, Rapid Eye Movement Sleep Disorder, Restless Legs Syndrome (RLS), Tardive Dyskinesia (TD), Acute Manic episode, Myoclonic seizures, Refractory absence Seizures
Associated Therapies
-

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-12-09
Last Posted Date
2016-04-25
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
40
Registration Number
NCT02312908
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Clobazam Use in Epilepsia Partialis Continua - Pilot Study

First Posted Date
2014-05-09
Last Posted Date
2018-05-09
Lead Sponsor
The Cooper Health System
Target Recruit Count
7
Registration Number
NCT02134366
Locations
🇺🇸

Cooper Universtiy Hospital, Camden, New Jersey, United States

Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus

First Posted Date
2013-06-05
Last Posted Date
2018-10-11
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
434
Registration Number
NCT01870024
Locations
🇫🇷

Département d'Anesthésie - Réanimation - SMUR - Hôpital Lariboisière, Paris, France

GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation

First Posted Date
2011-02-08
Last Posted Date
2011-12-14
Lead Sponsor
University Hospital, Geneva
Target Recruit Count
25
Registration Number
NCT01291316
Locations
🇨🇭

University Hospitals, Geneva, Switzerland

Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers

Phase 3
Completed
Conditions
Interventions
First Posted Date
2009-11-11
Last Posted Date
2010-08-11
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
17
Registration Number
NCT01011036
Locations
🇨🇭

Dep of Anesthesiology and Pain Therapy, University Hospital Bern, Bern, Switzerland

Evaluate Pharmacokinetics Of Two Different Pharmaceutical Oral Formulations Of Alprazolam And A Clonazepam Tablet In Mexican Healthy Population

First Posted Date
2008-12-18
Last Posted Date
2021-01-28
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
24
Registration Number
NCT00810316
Locations
🇲🇽

Pfizer Investigational Site, Col. Arenal Tepepan, Mexico D.F., Mexico

Bioavailability Study of Clonazepam ODT Under Fasting Conditions

First Posted Date
2008-04-04
Last Posted Date
2008-04-04
Lead Sponsor
Par Pharmaceutical, Inc.
Target Recruit Count
32
Registration Number
NCT00652912

Bioavailability Study of Clonazepam Tablets Under Fasting Conditions

First Posted Date
2008-04-04
Last Posted Date
2008-04-04
Lead Sponsor
Par Pharmaceutical, Inc.
Target Recruit Count
32
Registration Number
NCT00652639

Study of Intranasal Clonazepam in Adult Subjects With Epileptic Seizures

Phase 2
Completed
Conditions
Interventions
First Posted Date
2008-01-16
Last Posted Date
2014-07-01
Lead Sponsor
Jazz Pharmaceuticals
Target Recruit Count
45
Registration Number
NCT00594945
Locations
🇺🇸

Clinical Trials. inc., Little Rock, Arkansas, United States

🇺🇸

Ohio State University, Columbus, Ohio, United States

🇺🇸

Columbia Comprehensive Epilepsy Center, Neurological Institute, New York, New York, United States

and more 3 locations
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