Sertaconazole
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Sertaconazole is a topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
Sertaconazole is a topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
Sertaconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
