Dutasteride
- Generic Name
- Dutasteride
- Brand Names
- Avodart, Jalyn
- Drug Type
- Small Molecule
- Chemical Formula
- C27H30F6N2O2
- CAS Number
- 164656-23-9
- Unique Ingredient Identifier
- O0J6XJN02I
- Background
Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal mediato...
- Indication
Indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for BPH-related surgery alone or in combination with tamsulosin.
- Associated Conditions
- Benign Prostatic Hyperplasia (BPH), Symptomatic benign prostatic hyperplasia (BPH)
- Associated Therapies
- -
Biomarker Study of in Men With PSA Progression on Abi for CR or CS PC (Bio-STAMP)
- First Posted Date
- 2023-01-31
- Last Posted Date
- 2023-02-27
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Registration Number
- NCT05705700
Exploratory Clinical Trial of Safety and Efficacy of Daily Application of Topical Dutasteride in Men With Androgenic Alopecia.
- Conditions
- Interventions
- First Posted Date
- 2022-10-31
- Last Posted Date
- 2023-05-30
- Target Recruit Count
- 45
- Registration Number
- NCT05599243
- Locations
- 🇪🇸
Hospital Ramón y Cajal, Madrid, Spain
Efficacy and Safety of DKF-313 in Patients With Benign Prostatic Hyperplasia
- Conditions
- Interventions
- First Posted Date
- 2021-07-01
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Dongkook Pharmaceutical Co., Ltd.
- Target Recruit Count
- 667
- Registration Number
- NCT04947631
- Locations
- 🇰🇷
Ewha Womans University mokdong Hospital, Seoul, Korea, Republic of
A Study to Investigate the Pharmacokinetic Drug Interactions Between Dutasteride and Tadalafil in Healthy Male Subjects
- First Posted Date
- 2016-07-20
- Last Posted Date
- 2017-04-04
- Lead Sponsor
- Yuyu Pharma, Inc.
- Target Recruit Count
- 28
- Registration Number
- NCT02839122
Safety and Pharmacokinetic Characteristics of DKF-313
- Conditions
- Interventions
- First Posted Date
- 2015-02-02
- Last Posted Date
- 2021-07-06
- Lead Sponsor
- Dongkook Pharmaceutical Co., Ltd.
- Target Recruit Count
- 54
- Registration Number
- NCT02352311
- Locations
- 🇰🇷
Chonbuk National University Hospital, Jeonju, Jeollabuk-do, Korea, Republic of
A Phase II Neoadjuvant Study of Enzalutamide, Abiraterone Acetate, Dutasteride and Degarelix in Men With Localized Prostate Cancer Pre-prostatectomy
- Conditions
- First Posted Date
- 2014-06-10
- Last Posted Date
- 2015-01-26
- Lead Sponsor
- Kenneth Pienta, MD
- Registration Number
- NCT02159690
- Locations
- 🇺🇸
Johns Hopkins Hospital, Baltimore, Maryland, United States
ITT-5 Mechanisms of Spermatogenesis in Man
- Conditions
- Interventions
- First Posted Date
- 2014-05-28
- Last Posted Date
- 2019-12-18
- Lead Sponsor
- University of Washington
- Registration Number
- NCT02147964
- Locations
- 🇺🇸
University of Washington Medical Center (Health Sciences), Seattle, Washington, United States
Sexual Function in Men Receiving Dutasteride for Androgenetic Alopecia
- First Posted Date
- 2013-12-18
- Last Posted Date
- 2018-10-11
- Lead Sponsor
- Stiefel, a GSK Company
- Target Recruit Count
- 117
- Registration Number
- NCT02014584
- Locations
- 🇨🇳
GSK Investigational Site, Taipei, Taiwan
Safety and Pharmacokinetic Interaction Study of Tadalafil and Dutasteride
- First Posted Date
- 2013-09-16
- Last Posted Date
- 2015-01-26
- Lead Sponsor
- Dongkook Pharmaceutical Co., Ltd.
- Target Recruit Count
- 47
- Registration Number
- NCT01942551
- Locations
- 🇰🇷
Chungnam National University Hospital, Daejeon, Korea, Republic of
Finasteride, Dutasteride and Insulin Action
- First Posted Date
- 2013-08-14
- Last Posted Date
- 2013-08-14
- Lead Sponsor
- University of Birmingham
- Target Recruit Count
- 12
- Registration Number
- NCT01923090
- Locations
- 🇬🇧
Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom
Drug Development Updates
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