Allopurinol
- Generic Name
- Allopurinol
- Brand Names
- Aloprim, Zyloprim
- Drug Type
- Small Molecule
- Chemical Formula
- C5H4N4O
- CAS Number
- 315-30-0
- Unique Ingredient Identifier
- 63CZ7GJN5I
- Background
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals .
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- Indication
Allopurinol is indicated in :
1) the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
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- Associated Conditions
- Hyperuricemia, Primary Gout, Recurrent calcium oxalate calculi, Secondary gout, Calcium oxalate calculi Renal Calculi
- Associated Therapies
- -
Allopurinol and Endothelial Function in Diabetic CAD Patients
- First Posted Date
- 2017-12-28
- Last Posted Date
- 2017-12-28
- Lead Sponsor
- University Tunis El Manar
- Target Recruit Count
- 58
- Registration Number
- NCT03385135
- Locations
- 🇹🇳
Cardiology Department, Abderrahmen Mami Hospital, Ariana, Tunisia
PERL Continuous Glucose Monitoring (CGM) Study
- Conditions
- Interventions
- Other: Mean blood glucoseOther: Blood glucose CVOther: % time 70-180 mg/dLOther: % time below 54 mg/dLOther: % time above 180 mg/dLOther: % time above 250 mg/dLOther: MAGE (Mean amplitude of glucose excursions)Other: LBGI (Low Blood Glucose Index)Other: HBGI (High Blood Glucose Index)Drug: PlaceboDrug: Allopurinol
- First Posted Date
- 2017-11-07
- Last Posted Date
- 2022-03-29
- Lead Sponsor
- Joslin Diabetes Center
- Target Recruit Count
- 175
- Registration Number
- NCT03334318
- Locations
- 🇺🇸
ICAHN School of Medicine at Mount Sinai, New York, New York, United States
🇺🇸Washington University, Saint Louis, Missouri, United States
🇨🇦Unversity of Calgary, Calgary, Alberta, Canada
Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome
- Conditions
- Interventions
- First Posted Date
- 2017-05-22
- Last Posted Date
- 2023-07-11
- Lead Sponsor
- University Hospital Tuebingen
- Target Recruit Count
- 760
- Registration Number
- NCT03162653
- Locations
- 🇫🇮
Helsingin Ja Uudenmaan Sairaanhoitopiirin Kuntayhtymä, Helsinki, Finland
🇵🇱Uniwersytet Medyczny Im Karola Marcinkowskiego W Poznaniu, Poznań, Poland
🇪🇪Tartu Ulikool, Tartu, Estonia
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
- Conditions
- Interventions
- Drug: AllopurinolDrug: CytarabineDrug: Daunorubicin HydrochlorideDrug: Vincristine SulfateDrug: DexamethasoneDrug: Pegylated L-AsparaginaseDrug: MethotrexateProcedure: Bone Marrow Aspiration and BiopsyDrug: CyclophosphamideDrug: MercaptopurineBiological: RituximabDrug: ThioguanineDrug: DoxorubicinOther: Laboratory Biomarker AnalysisBiological: Inotuzumab Ozogamicin
- First Posted Date
- 2017-05-12
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- Alliance for Clinical Trials in Oncology
- Target Recruit Count
- 310
- Registration Number
- NCT03150693
- Locations
- 🇺🇸
Alaska Women's Cancer Care, Anchorage, Alaska, United States
🇺🇸Anchorage Oncology Centre, Anchorage, Alaska, United States
🇺🇸Katmai Oncology Group, Anchorage, Alaska, United States
Gender Differences in the Metabolic Effects of Uric Acid
- First Posted Date
- 2017-03-10
- Last Posted Date
- 2019-04-17
- Lead Sponsor
- University of Missouri-Columbia
- Registration Number
- NCT03076684
- Locations
- 🇺🇸
University of Missouri, Columbia, Missouri, United States
Optimizing 6-mercaptopurine Therapy in Pediatric Acute Lymphoblastic Leukemia by Using Allopurinol
- Conditions
- Interventions
- First Posted Date
- 2017-01-16
- Last Posted Date
- 2017-01-16
- Lead Sponsor
- Vastra Gotaland Region
- Target Recruit Count
- 60
- Registration Number
- NCT03022747
- Locations
- 🇫🇮
Dept of Pediatrics and Adolescents, Oulu University Hospital, Box 23, 90029 OYS, Finland, Oulu, Finland
🇸🇪Childrens' Cancer Centre, Queen Silvias Childrens and Adolescents Hospital, Gothenburg, Sweden
🇸🇪Linköping University Hospital, Dept of Pediatrics, Linköping, Sweden
Allopurinol in Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis
- Conditions
- Interventions
- First Posted Date
- 2016-12-14
- Last Posted Date
- 2016-12-14
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 100
- Registration Number
- NCT02992652
The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics
- First Posted Date
- 2016-11-06
- Last Posted Date
- 2020-06-23
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 27
- Registration Number
- NCT02956278
- Locations
- 🇺🇸
Open Medicine Institute, Mountain View, California, United States
Microalbuminuria and Allopurinol in Type 1 Diabetes
- Conditions
- Interventions
- First Posted Date
- 2016-07-12
- Last Posted Date
- 2018-09-10
- Lead Sponsor
- Peter Rossing
- Target Recruit Count
- 30
- Registration Number
- NCT02829177
- Locations
- 🇩🇰
Steno Diabetes Center, Gentofte, Denmark
Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines
- Conditions
- Interventions
- First Posted Date
- 2016-06-13
- Last Posted Date
- 2016-06-13
- Target Recruit Count
- 320
- Registration Number
- NCT02797028
- Locations
- 🇨🇳
General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, Guangdong, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.