Allopurinol

Generic Name: Allopurinol

Brand Names: Aloprim, Zyloprim

Drug Type: Small Molecule

Chemical Formula: C_₅H_₄N_₄O

CAS Number: 315-30-0

Unique Ingredient Identifier: 63CZ7GJN5I

Background: Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals .
...

Indication: Allopurinol is indicated in :

1) the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
...

Associated Conditions: Hyperuricemia, Primary Gout, Recurrent calcium oxalate calculi, Secondary gout, Calcium oxalate calculi Renal Calculi

Associated Therapies: -

Clinical Trials

Effect of Allopurinol and Febuxostat on Urinary 2,8-Dihydroxyadenine Excretion

Phase 4

Completed

Conditions: Adenine Phosphoribosyltransferase Deficiency

Interventions: Drug: Allopurinol
Drug: Febuxostat

First Posted Date: 2016-04-27

Last Posted Date: 2024-04-09

Lead Sponsor: Landspitali University Hospital

Target Recruit Count: 9

Registration Number: NCT02752633

Locations: 🇮🇸
Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland

Whole Blood Bactericidal Activity Against Mycobacterium Tuberculosis of Pyrazinamide Plus Allopurinol in Healthy Volunteers

Phase 1

Completed

Conditions: Tuberculosis

Interventions: Drug: Pyrazinamide
Drug: Allopurinol

First Posted Date: 2016-03-07

Last Posted Date: 2017-04-13

Lead Sponsor: National University Hospital, Singapore

Target Recruit Count: 12

Registration Number: NCT02700347

Locations: 🇸🇬
National University Hospital, Singapore, Singapore, Singapore

Allo HSCT Using RIC for Hematological Diseases

Phase 2

Completed

Conditions: Chronic Myelogenous Leukemia
Lymphoplasmacytic Lymphoma
Mantle-Cell Lymphoma
Lymphoblastic Lymphoma
Acute Myelogenous Leukemia
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Burkitt's Lymphoma
Hematological Diseases
B-Cell Lymphoma

Interventions: Drug: Allopurinol
Drug: Fludarabine
Drug: Cyclophosphamide
Drug: ATG
Radiation: TBI
Drug: Tacrolimus
Drug: MMF
Biological: Peripheral Blood Stem Cells
Biological: Related or Unrelated Bone Marrow Cells

First Posted Date: 2016-01-21

Last Posted Date: 2023-09-21

Lead Sponsor: Masonic Cancer Center, University of Minnesota

Target Recruit Count: 156

Registration Number: NCT02661035

Locations: 🇺🇸
Masonic Cancer Center at University of Minnesota, Minneapolis, Minnesota, United States

Zurig (Febuxostat) 40mg Efficacy and Safety Trial

Phase 4

Completed

Conditions: Hyperuricemia

Interventions: Drug: Allopurinol
Drug: Febuxostat

First Posted Date: 2015-11-09

Last Posted Date: 2019-08-01

Lead Sponsor: Getz Pharma

Target Recruit Count: 50

Registration Number: NCT02600780

Locations: 🇵🇰
Dow University of Health Sciences, Karachi, Sindh, Pakistan

Optimal Administration of Allopurinol in Dialysis Patients

Phase 4

Completed

Conditions: Gout
Renal Insufficiency

Interventions: Drug: Allopurinol

First Posted Date: 2015-06-22

Last Posted Date: 2016-09-13

Lead Sponsor: Maisonneuve-Rosemont Hospital

Target Recruit Count: 50

Registration Number: NCT02477488

Locations: 🇨🇦
Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Genetics of Hyperuricemia Therapy in Hmong

Completed

Conditions: Hyperuricemia, Gout

Interventions: Drug: Allopurinol

First Posted Date: 2015-02-25

Last Posted Date: 2019-07-15

Lead Sponsor: University of Minnesota

Target Recruit Count: 80

Registration Number: NCT02371421

Locations: 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States

Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension?

Phase 4

Completed

Conditions: Hypertrophy, Left Ventricular
Hypertension

Interventions: Drug: Placebo
Drug: Allopurinol

First Posted Date: 2014-09-11

Last Posted Date: 2019-09-17

Lead Sponsor: University of Dundee

Target Recruit Count: 72

Registration Number: NCT02237339

Locations: 🇬🇧
University of Dundee, Ninewells Hospital, Dundee, Tayside, United Kingdom

Prednisone for Heart Failure Patients With Hyperuricemia

Phase 2

Completed

Conditions: Heart Failure, Hyperuricemia

Interventions: Drug: Prednisone
Drug: Allopurinol

First Posted Date: 2014-05-02

Last Posted Date: 2018-10-16

Lead Sponsor: Hebei Medical University

Target Recruit Count: 205

Registration Number: NCT02129764

XILO-FIST, the Effect of Allopurinol on the Brain Heart and Blood Pressure After Stroke

Phase 4

Completed

Conditions: Ischaemic Stroke

Interventions: Drug: Placebo
Drug: Allopurinol

First Posted Date: 2014-04-24

Last Posted Date: 2021-11-12

Lead Sponsor: NHS Greater Glasgow and Clyde

Target Recruit Count: 464

Registration Number: NCT02122718

Locations: 🇬🇧
NHS Lanarkshire, Airdrie, United Kingdom
🇬🇧
Guys and St Thomas NHS Foundation Trust, London, United Kingdom
🇬🇧
South West Acute Hospital, Enniskillen, United Kingdom

and more 18 locations

Safety and Efficacy of Oral Febuxostat in Subjects With Gout

Phase 3

Completed

Conditions: Gout

Interventions: Drug: Allopurinol
Drug: Febuxostat

First Posted Date: 2014-03-10

Last Posted Date: 2016-02-03

Lead Sponsor: Xijing Hospital

Target Recruit Count: 504

Registration Number: NCT02082769

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