Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on many targets at once. Nitrofurantoin is a second line treatment to trimethoprim/sulfamethoxazole.
Nitrofurantoin was granted FDA approval on 6 February 1953.
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
Nitrofurantoin and Urinary Tract Infections (UTIs)
- Conditions
- Urinary Tract Infections
- Interventions
- Drug: Placebo
- First Posted Date
- 2008-05-15
- Last Posted Date
- 2016-09-27
- Lead Sponsor
- University of Pittsburgh
- Target Recruit Count
- 10
- Registration Number
- NCT00678041
- Locations
- 🇺🇸
Magee Womens Hospital, Pittsburgh, Pennsylvania, United States
Food Study of Nitrofurantoin Monohydrate/Macrocrystals Capsules 100 mg and Macrobid® Capsules 100 mg
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Mylan Pharmaceuticals Inc
- Target Recruit Count
- 71
- Registration Number
- NCT00649285
- Locations
- 🇺🇸
Kendle International Inc., Morgantown, West Virginia, United States
Food Study of Nitrofurantoin Macrocrystals 100 mg Capsules and Macrodantin® 100 mg
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Mylan Pharmaceuticals Inc
- Target Recruit Count
- 28
- Registration Number
- NCT00649506
- Locations
- 🇺🇸
Kendle International Inc., Morgantown, West Virginia, United States
Short Course Nitrofurantoin for Acute Cystitis
- Conditions
- Urinary Tract Infection
- Interventions
- Drug: TMP/SMX DS twice daily x 3 days
- First Posted Date
- 2006-10-24
- Last Posted Date
- 2014-06-05
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 338
- Registration Number
- NCT00391651
- Locations
- 🇺🇸
University of WA, Seattle, Washington, United States
Nitrofurantoin Macrocrystals 3 Days Versus 7 Days in the Treatment of Women With Uncomplicated Cystitis
- Conditions
- Cystitis
- First Posted Date
- 2006-08-09
- Last Posted Date
- 2007-03-02
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 400
- Registration Number
- NCT00361998
- Locations
- 🇮🇱
Research Unit, Clalit Health Services, Haifa and Western Galillee District, Haifa, Israel
Drug Development Updates
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