磺胺林

概览

Sulfametopyrazine is an antibiotic used in the treatment or prevention of bacterial infections and malaria.

作用机制

Sulfametopyrazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. Para-aminobenzoic acid (PABA), a substrate of the enzyme is prevented from binding. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

适应症

For the treatment of urinary tract infection and chronic bronchitis.

• Malaria