Guaiacol

Overview

Guaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.

Indication

It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation; guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation.

Associated Conditions

Productive cough
Chest congestion
Dry socket syndrome

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Transpulmin Suppository and Guaiacol Compared to Transpulmin Syrup in Pediatric Participants With Productive Cough	2015/10/21	NCT02581397	Phase 3	Terminated	Ache Laboratorios Farmaceuticos S.A.
Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin	2010/05/07	NCT01119534	Phase 3	UNKNOWN	Azidus Brasil

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Dry Socket	Dentsply LLC, Professional Division, trading as "Sultan Healthcare"	0699-0404	DENTAL	0.0416 g in 1 g	1/26/2024

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
No TGA approvals found for this drug.

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
GOUTTES DENTAIRES	lab valmo enregistré, division of technilab inc.	00542873	Liquid - Dental	6.6 G / 100 ML	12/31/1983
DEMO CINEOL INJ	sabex inc	00456608	Liquid - Intramuscular	167 MG / ML	12/31/1951
DEMO-CINEOL ENFANTS/CHILDREN	Laboratoires Confab Inc	00319724	Suppository - Rectal	90 MG	12/31/1977
VALDA PASTILLES	bayer inc consumer care	02154587	Lozenge - Oral	.016 MG / LOZ	12/31/1995
PASTILLES VALDA	labs valda	00534498	Lozenge - Oral	.016 MG	12/31/1981
PULMOSIRUM PLUS EXPECTORANT	nutribon (1986) inc.	00805599	Syrup - Oral	.01 MG / ML	12/31/1989
PULMO SEPTOL SIROP	les laboratoires bio-santé inc.	00721301	Syrup - Oral	.01 MG / ML	12/31/1989
ANALGESIC BALM	stanley pharmaceuticals, a division of vita health products inc.	00180157	Ointment - Topical	1.25 %	12/31/1965
PULMOSIRUM EXPECTORANT SYRUP	nutribon (1986) inc.	00805602	Syrup - Oral	.01 MG / ML	12/31/1989
DEMO-CINEOL ADULTES/ADULTS	Laboratoires Confab Inc	00319716	Suppository - Rectal	180 MG	12/31/1986

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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