Sildenafil
- Generic Name
- Sildenafil
- Brand Names
- Liqrev, Revatio, Viagra, Vizarsin, Sildenafil Actavis, Sildenafil ratiopharm, Granpidam, Sildenafil Teva, Mysildecard
- Drug Type
- Small Molecule
- Chemical Formula
- C22H30N6O4S
- CAS Number
- 139755-83-2
- Unique Ingredient Identifier
- 3M7OB98Y7H
- Background
In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate (cGMP) by inhibiting cGMP specific phosphodiesterase type 5 (PDE5) . The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently faci...
- Indication
Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor that is predominantly employed for two primary indications:
(1) the treatment of erectile dysfunction ; and
(2) treatment of pulmonary hypertension, where:
...
- Associated Conditions
- Erectile Dysfunction, NYHA Functional Class II-III Pulmonary arterial hypertension, Premature Ejaculation, Pulmonary Arterial Hypertension (PAH)
- Associated Therapies
- -
Chronic Sildenafil for Severe Diaphragmatic Hernia
- Conditions
- Interventions
- First Posted Date
- 2005-08-23
- Last Posted Date
- 2021-01-13
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 9
- Registration Number
- NCT00133679
- Locations
- 🇺🇸
Children's Hospital of Los Angeles, Los Angeles, California, United States
🇺🇸University of California San Francisco Children's Hospital, San Francisco, California, United States
🇺🇸Children's Memorial Hospital, Chicago, Illinois, United States
Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia
- Conditions
- First Posted Date
- 2003-03-13
- Last Posted Date
- 2019-11-22
- Target Recruit Count
- 39
- Registration Number
- NCT00056433
- Locations
- 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States
Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2014-03-04
- Lead Sponsor
- Carelon Research
- Target Recruit Count
- 1000
- Registration Number
- NCT00000623
- Locations
- 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Weill Medical College of Cornell University, New York, New York, United States
🇺🇸Children's Hospital Oakland, Oakland, California, United States
Drug Development Updates
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