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Etacrynic acid

Generic Name
Etacrynic acid
Brand Names
Edecrin
Drug Type
Small Molecule
Chemical Formula
C13H12Cl2O4
CAS Number
58-54-8
Unique Ingredient Identifier
M5DP350VZV

Overview

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Background

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Indication

For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

Associated Conditions

  • Ascites
  • Congenital Heart Disease (CHD)
  • Edema
  • Nephrotic Syndrome

Clinical Trials

Phase 1
Completed
Posted: 2014/01/31
Sponsor:
Molly Walsh
Phase 3
Completed
Posted: 2012/06/27
Sponsor:
Bambino Gesù Hospita...

FDA Approved Products

Ethacrynic Acid
Manufacturer:Upsher-Smith Laboratories, LLC
Route:ORAL
Strength:25 mg in 1 1
Approved: 2021/01/22
NDC:0832-1690
Ethacrynic acid
Manufacturer:Agnitio Inc.
Route:ORAL
Strength:25 mg in 1 1
Approved: 2021/01/28
NDC:72134-003
Ethacrynic acid
Manufacturer:TRUPHARMA LLC
Route:ORAL
Strength:25 mg in 1 1
Approved: 2023/12/07
NDC:52817-367
Ethacrynic Acid
Manufacturer:Amneal Pharmaceuticals NY LLC
Route:ORAL
Strength:25 mg in 1 1
Approved: 2023/12/30
NDC:69238-1126
EDECRIN
Manufacturer:Avera McKennan Hospital
Route:ORAL
Strength:25 mg in 1 1
Approved: 2015/12/10
NDC:69189-0371

Singapore Approved Products

No Singapore products found for this drug

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