Levocarnitine
- Generic Name
- Levocarnitine
- Brand Names
- Carnitor
- Drug Type
- Small Molecule
- Chemical Formula
- C7H15NO3
- CAS Number
- 541-15-1
- Unique Ingredient Identifier
- 0G389FZZ9M
- Background
Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
- Indication
⑴用于继发性肉碱缺乏症。主要用于慢性肾衰长期血透患者因肉碱缺乏产生的一系列并发症状，临床表现如心肌病、骨骼肌病、心律失常、高脂血症，以及低血压和透析中肌痉挛等。
⑵用于罕见病β-酮硫解酶缺乏症（BKD）和原发性肉碱缺乏症（PCD）。
⑶用于罕见病戊二酸Ⅰ型。
⑷用于维持罕见病同型半胱氨酸血症引起的血液游离肉碱的正常水平。
- Associated Conditions
- Carnitine Deficiency, Congenital carnitine deficiency, Secondary Carnitine deficiency
NPPA Sets Retail Prices for 84 Drugs Including Empagliflozin Combinations Following Patent Expiry
• India's National Pharmaceutical Pricing Authority (NPPA) has fixed retail prices for 84 new drug formulations, including 36 combinations containing the recently off-patent diabetes medication empagliflozin.
• The price regulations follow the March 11, 2025 expiry of Boehringer Ingelheim's empagliflozin patent, opening the market to multiple pharmaceutical companies including Mankind Pharma, Lupin, and Alkem Laboratories.
• Beyond diabetes medications, the NPPA's pricing decisions also cover anti-hypertensive combinations containing telmisartan and metoprolol, as well as anti-inflammatory formulations with paracetamol and mefenamic acid.
L-Carnitine Supplementation Improves Bowel Function in Children on Ketogenic Diets for Drug-Resistant Epilepsy
• A study on pediatric patients with drug-resistant epilepsy (DRE) found that L-carnitine supplementation during ketogenic diet therapy (KDT) improves bowel function.
• L-carnitine supplementation led to increased frequency of defecation and softer stool consistency in children on KDT, indicating improved gastrointestinal health.
• The research showed a positive correlation between antral length and improvement of gastro-intestinal symptoms with L-carnitine supplementation during KDT.
• L-carnitine supplementation during KDT also demonstrated a positive effect on fasting lipid profiles by significantly increasing HDL levels in pediatric patients.
Cemiplimab Shows Promise in Advanced Basal Cell Carcinoma After Hedgehog Inhibitor Failure
• Cemiplimab demonstrates efficacy in patients with locally advanced or metastatic basal cell carcinoma (mBCC) who have progressed on or are intolerant to hedgehog pathway inhibitors (HHIs).
• The phase 2 Study 1620 showed a 22% overall response rate by independent central review, with a median progression-free survival of 10 months in advanced BCC patients treated with cemiplimab.
• Common adverse events associated with HHIs, such as muscle spasms, taste changes, and weight loss, often lead to treatment discontinuation, highlighting the need for alternative therapies like cemiplimab.
• Immunotherapy with cemiplimab presents a viable option for advanced BCC patients, particularly those who cannot tolerate or have progressed on HHIs, with manageable safety profiles and durable responses.
One-Week Elderberry Juice Treatment Increases Postprandial Carbohydrate Oxidation
A pilot study found that consuming 100% elderberry juice for one week significantly increased postprandial carbohydrate oxidation in overweight and obese adults, without affecting serum glucose or insulin levels. The study suggests elderberry juice could influence metabolic flexibility, though further research is needed to confirm these findings.
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