MedPath

Urea

Generic Name
Urea
Brand Names
Cem-urea, Umecta, Utopic
Drug Type
Small Molecule
Chemical Formula
CH4N2O
CAS Number
57-13-6
Unique Ingredient Identifier
8W8T17847W

Overview

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Background

A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Indication

Urea is used topically for debridement and promotion of normal healing of hyperkeratotic surface lesions, particularly where healing is retarded by local infection, necrotic tissue, fibrinous or purulent debris or eschar. Urea is useful for the treatment of hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, keratosis, keratoderma, corns and calluses, as well as damaged, devitalized and ingrown nails.

Associated Conditions

  • Allergic Skin Reaction
  • Atopic Dermatitis
  • Contact Dermatitis
  • Dermatitis
  • Dry Eyes
  • Dry Skin
  • Dry Skin; Eczema
  • Eczema, Dyshidrotic
  • Eye pruritus
  • Helicobacter Pylori Infection
  • Insect Bites
  • Lichen Planus (LP)
  • Neurodermatitis
  • Nummular Dermatitis
  • Psoriasis
  • Seborrheic Dermatitis
  • Sunburn
  • Anal eczema
  • Calluses

FDA Approved Products

Urea 39.5% with 2% Salicylic Acid
Manufacturer:PureTek Corporation
Route:TOPICAL
Strength:39.5 g in 100 g
Approved: 2023/03/24
NDC:59088-210
HYALURONIC ACID SODIUM SALT 1% / TACROLIMUS 0.1% / UREA 20%
Manufacturer:Sincerus Florida, LLC
Route:TOPICAL
Strength:20 g in 100 g
Approved: 2019/05/16
NDC:72934-2097
UREA 40%
Manufacturer:Gabar Health Sciences Corp.
Route:TOPICAL
Strength:40 g in 100 g
Approved: 2023/10/21
NDC:82429-308
UREA
Manufacturer:Bantry Pharma, LLC
Route:TOPICAL
Strength:400 mg in 1 g
Approved: 2023/09/06
NDC:81542-201
UREA
Manufacturer:AKRON PHARMA INC
Route:TOPICAL
Strength:40 g in 100 g
Approved: 2023/03/11
NDC:71399-8455

Singapore Approved Products

HYDROCORTISONE 1% ET UREA 5% CREAM
Manufacturer:ICM PHARMA PTE. LTD.
Form:CREAM
Strength:5% w/w
Online:Yes
Approved: 1989/05/22
Approval:SIN02881P
AXCEL UREA CREAM 10% w/w
Manufacturer:KOTRA PHARMA (M) SDN BHD
Form:CREAM
Strength:10% w/w
Online:Yes
Approved: 1999/04/07
Approval:SIN10864P
UCORT CREAM
Manufacturer:Y S P INDUSTRIES (M) SDN BHD
Form:CREAM
Strength:100 mg/g
Online:Yes
Approved: 1996/05/27
Approval:SIN08726P
U O CREAM 10%
Manufacturer:Y S P INDUSTRIES (M) SDN BHD
Form:CREAM
Strength:100 mg/g
Online:Yes
Approved: 1995/09/19
Approval:SIN08347P

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