Carvedilol
- Generic Name
- Carvedilol
- Brand Names
- Coreg
- Drug Type
- Small Molecule
- Chemical Formula
- C24H26N2O4
- CAS Number
- 72956-09-3
- Unique Ingredient Identifier
- 0K47UL67F2
- Background
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. It is currently used to treat heart failure, left ventricular dysfunction, and hypertension. The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.
Carvedilol was granted FDA approval on 14 September 1995.
- Indication
Carvedilol is indicated to treat mild to severe heart failure, left ventricular dysfunction after myocardial infarction with ventricular ejection fraction ≤40%, or hypertension.
- Associated Conditions
- Atrial Fibrillation, Chronic Stable Angina Pectoris, Hypertension, LVEF ≤40% Left ventricular dysfunction, NYHA Class I or II heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class III), Chronic heart failure with reduced ejection fraction (NYHA Class IV)
- Associated Therapies
- -
Effect Of Carvedilol Versus Metoprolol On Glycemic Control In Patients With Type II Diabetes And Hypertension
- Conditions
- Hypertension
- First Posted Date
- 2003-05-16
- Last Posted Date
- 2015-04-14
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 501
- Registration Number
- NCT00060931
- Locations
- 🇺🇸
GSK Investigational Site, Springfield, Virginia, United States
Glycemic Control Of Carvedilol Versus Metoprolol In Patients With Type II Diabetes Mellitus And Hypertension
- Conditions
- Hypertension
- First Posted Date
- 2003-05-16
- Last Posted Date
- 2015-04-15
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 1210
- Registration Number
- NCT00060918
- Locations
- 🇺🇸
GSK Investigational Site, Milwaukee, Wisconsin, United States
Safety and Efficacy Study of Carvedilol to Treat Children With Congestive Heart Failure
- First Posted Date
- 2003-01-23
- Last Posted Date
- 2008-12-25
- Lead Sponsor
- Shaddy, Robert, M.D.
- Target Recruit Count
- 161
- Registration Number
- NCT00052026
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸University of Colorado, Denver, Colorado, United States
🇺🇸Columbia University, New York, New York, United States
The Safety and Efficacy of Adjunct Carvedilol in Children With Moderate Heart Failure
- Conditions
- Heart Diseases
- First Posted Date
- 2000-03-09
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Registration Number
- NCT00004854
- Locations
- 🇺🇸
Washington University School of Medicine, St. Louis, Missouri, United States
Effects of Carvedilol on Cocaine Use in Humans - 11
- Conditions
- Cocaine-Related Disorders
- First Posted Date
- 1999-09-21
- Last Posted Date
- 2017-01-12
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Registration Number
- NCT00000294
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Drug Development Updates
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