• Simcha Therapeutics initiates two clinical studies to evaluate ST-067, a decoy-resistant IL-18, in acute myeloid leukemia/myelodysplastic syndrome and multiple myeloma.
• The AML/MDS study (NCT06492707) will assess ST-067 in patients with persistent or recurrent disease post-hematopoietic cell transplantation.
• The multiple myeloma study (NCT06588660) will investigate ST-067 in combination with teclistamab to enhance T-cell fitness and persistence.
• Preclinical data supports ST-067's potential in hematologic cancers, with findings presented at the 2024 ASH Annual Meeting.