Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
Study to Evaluate the Efficacy of Immunosuppression in Myocarditis or Inflammatory Cardiomyopathy.
- First Posted Date
- 2020-12-04
- Last Posted Date
- 2024-03-28
- Lead Sponsor
- Medical University of Warsaw
- Target Recruit Count
- 100
- Registration Number
- NCT04654988
- Locations
- 🇵🇱
First Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Early Use of Long-acting Tacrolimus in Lung Transplant Recipients
- First Posted Date
- 2020-07-14
- Last Posted Date
- 2024-01-10
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 48
- Registration Number
- NCT04469842
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Effect of the Exclusive Enteral Nutrition Combined With Azathioprine for Remission of Crohn's Diseases After Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-11-13
- Last Posted Date
- 2023-10-17
- Lead Sponsor
- Zhu Weiming
- Target Recruit Count
- 54
- Registration Number
- NCT04160325
- Locations
- 🇨🇳
Department of General Surgery, Jinling hosptal,Medical School of Nanjing University, Nanjing, Jiangsu, China
Multicenter Registry of Pediatric Lupus Nephritis in China
- First Posted Date
- 2019-01-03
- Last Posted Date
- 2019-04-05
- Lead Sponsor
- Xiqiang Dang
- Target Recruit Count
- 1200
- Registration Number
- NCT03791827
- Locations
- 🇨🇳
The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Post-Operative Crohn's Disease Outcome in Children
- First Posted Date
- 2018-09-24
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- Schneider Children's Medical Center, Israel
- Target Recruit Count
- 100
- Registration Number
- NCT03681652
- Locations
- 🇮🇱
Schneider Children's Hospital, Petach Tikva, Israel
Disease-Modifying Treatments for Myasthenia Gravis
- Conditions
- Interventions
- First Posted Date
- 2018-04-06
- Last Posted Date
- 2021-02-03
- Lead Sponsor
- Duke University
- Target Recruit Count
- 167
- Registration Number
- NCT03490539
- Locations
- 🇨🇦
University of Alberta Hospital, Faculty of Medicine, Edmonton, Alberta, Canada
🇺🇸University at Buffalo, SUNY, Buffalo, New York, United States
🇺🇸University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid Arthritis
- Conditions
- Interventions
- First Posted Date
- 2018-02-28
- Last Posted Date
- 2022-04-28
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 84
- Registration Number
- NCT03449758
- Locations
- 🇫🇷
Investigational Site Number 250014, Caen, France
🇫🇷Investigational Site Number 250006, Besancon, France
🇫🇷Investigational Site Number 250016, Bordeaux, France
Treatment of Rheumatoid Arthritis With DMARDs: Predictors of Response
- Conditions
- Interventions
- First Posted Date
- 2018-01-30
- Last Posted Date
- 2024-06-24
- Lead Sponsor
- University of Nebraska
- Target Recruit Count
- 400
- Registration Number
- NCT03414502
- Locations
- 🇺🇸
University of Nebraska Medical Center, Omaha, Nebraska, United States
Evaluation of the Clinical and Immunological Impact of Two Therapeutic Strategies in Chronic Inflammatory Diseases
- Conditions
- Interventions
- First Posted Date
- 2017-12-12
- Last Posted Date
- 2019-02-15
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 9
- Registration Number
- NCT03370601
- Locations
- 🇫🇷
CHRU, Hôpital Claude Huriez, Lille, France
Tocilizumab vs Azathioprine in Neuromyelitis Optica Spectrum Disorders
- Conditions
- Interventions
- First Posted Date
- 2017-11-22
- Last Posted Date
- 2019-10-24
- Lead Sponsor
- Tianjin Medical University General Hospital
- Target Recruit Count
- 118
- Registration Number
- NCT03350633
- Locations
- 🇨🇳
Tianjin Medical University General Hospital, Tianjin, Tianjin, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.