Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
The Iguratimod Effect on Lupus Nephritis (IGeLU)
- Conditions
- Interventions
- First Posted Date
- 2016-10-18
- Last Posted Date
- 2018-12-19
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT02936375
- Locations
- 🇨🇳
RenJi Hospital, Shanghai, Shanghai, China
🇨🇳Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China
Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis
- First Posted Date
- 2016-09-14
- Last Posted Date
- 2023-06-22
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 70
- Registration Number
- NCT02900443
- Locations
- 🇳🇱
Jeroen Bosch Ziekenhuis, Den Bosch, Netherlands
🇧🇪University Hospital Antwerpen, Antwerpen, Belgium
🇳🇱Vrije Universiteit Medisch Centrum, Amsterdam, Netherlands
Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis
- Conditions
- Interventions
- First Posted Date
- 2016-01-01
- Last Posted Date
- 2017-03-06
- Target Recruit Count
- 75
- Registration Number
- NCT02645565
- Locations
- 🇮🇳
Department of Clinical Immunology , Jawaharlal Institute of Post graduate Medical Educationa and Research, Pondicherry, India
Tolerization Reduces Intolerance to Pegloticase and Prolongs the Urate Lowering Effect
- First Posted Date
- 2015-11-06
- Last Posted Date
- 2021-10-11
- Lead Sponsor
- Ampel BioSolutions, LLC
- Target Recruit Count
- 132
- Registration Number
- NCT02598596
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
🇺🇸University of Alabama at Birminingham, Birmingham, Alabama, United States
🇺🇸Rheumatology Associates of North Alabama, Huntsville, Alabama, United States
Azathioprine Based on Endoscopy After Clinical Remission in Moderate to Severe Ulcerative Colitis
- First Posted Date
- 2015-10-20
- Last Posted Date
- 2019-08-14
- Lead Sponsor
- Kyungpook National University Hospital
- Target Recruit Count
- 16
- Registration Number
- NCT02579733
- Locations
- 🇰🇷
Kyungpook National University Hospital, Daegu, Korea, Republic of
Top-down Infliximab Study in Kids With Crohn's Disease
- Conditions
- Interventions
- First Posted Date
- 2015-08-07
- Last Posted Date
- 2024-03-05
- Lead Sponsor
- Erasmus Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT02517684
- Locations
- 🇳🇱
Academic Medical Center, Amsterdam, Netherlands
🇳🇱Amphia Hospital, Breda, Netherlands
🇳🇱Radboud University Medical Center, Nijmegen, Netherlands
Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial
- Conditions
- Interventions
- First Posted Date
- 2015-06-04
- Last Posted Date
- 2017-02-15
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 57
- Registration Number
- NCT02463331
Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE
- Conditions
- Interventions
- First Posted Date
- 2015-05-14
- Last Posted Date
- 2022-03-14
- Lead Sponsor
- Chinese SLE Treatment And Research Group
- Target Recruit Count
- 50
- Registration Number
- NCT02444728
- Locations
- 🇨🇳
Beijng Hospital, Beijing, China
🇨🇳the Affiliated Hospital to Bangbu Medical University, Bangbu, Anhui, China
🇨🇳Hebei Provincial Hospital, Shijiazhuang, Hebei, China
A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
- Conditions
- Interventions
- First Posted Date
- 2015-04-24
- Last Posted Date
- 2023-05-31
- Target Recruit Count
- 65
- Registration Number
- NCT02425852
- Locations
- 🇫🇷
APHP- Hopital BEAUJON, Clichy, France
🇫🇷Hopital St Antoine, Paris, France
🇫🇷Chu Besancon, Besancon, France
Evaluate if Response to Infliximab or Adalimumab May be Regained With an Immunomodulator
- Conditions
- Interventions
- First Posted Date
- 2015-04-09
- Last Posted Date
- 2019-11-04
- Lead Sponsor
- Indiana University
- Target Recruit Count
- 3
- Registration Number
- NCT02413047
- Locations
- 🇺🇸
Indiana University Hospital, Indianapolis, Indiana, United States
Drug Development Updates
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