Azathioprine
- Generic Name
- Azathioprine
- Brand Names
- Azasan, Imuran, Jayempi
- Drug Type
- Small Molecule
- Chemical Formula
- C9H7N7O2S
- CAS Number
- 446-86-6
- Unique Ingredient Identifier
- MRK240IY2L
- Background
Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic index. Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transp...
- Indication
Azathioprine is indicated to treat rheumatoid arthritis and prevent renal transplant rejection.
- Associated Conditions
- Atopic Dermatitis, Crohn's Disease (CD), Immune Thrombocytopenia (ITP), Kidney Transplant Rejection, Lupus Nephritis, Multiple Sclerosis, Pericarditis, Psoriasis, Rheumatoid Arthritis, Uveitis
- Associated Therapies
- -
Thiopurine Induced Pancreatitis in IBD Patients
- First Posted Date
- 2014-11-04
- Last Posted Date
- 2021-03-18
- Lead Sponsor
- Shaare Zedek Medical Center
- Registration Number
- NCT02281799
- Locations
- ๐ฎ๐ฑ
Shaare Zedek, Jerusalem, Israel
Azathioprine in the Prevention of Ileal Crohn's Disease Postoperative Recurrence.
- First Posted Date
- 2014-09-23
- Last Posted Date
- 2015-05-29
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 63
- Registration Number
- NCT02247258
- Locations
- ๐จ๐ฟ
Univerzity Karlovy, Prague, Czech Republic
๐ฌ๐ทEvangelismos Hospital, Athens, Greece
๐ง๐ชImelda Ziekenhuis, Bonheiden, Belgium
A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy
- Conditions
- Interventions
- First Posted Date
- 2014-06-27
- Last Posted Date
- 2022-08-03
- Target Recruit Count
- 211
- Registration Number
- NCT02177071
- Locations
- ๐ฆ๐บ
St Vincent Hospital, Melbourne, Australia
๐ซ๐ทChu Clermont-Ferrand, Clermont-ferrand, Auvergne Rhone Alpes, France
๐ซ๐ทCHU LYON, Pierre Benite, Auvergne Rhone Alpes, France
Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver Cancer
- Conditions
- Interventions
- First Posted Date
- 2014-03-07
- Last Posted Date
- 2024-01-30
- Lead Sponsor
- Baylor Research Institute
- Target Recruit Count
- 336
- Registration Number
- NCT02081755
- Locations
- ๐บ๐ธ
Washington University School of Medicine, Saint Louis, Missouri, United States
๐บ๐ธMayo Clinic, Rochester, Minnesota, United States
๐บ๐ธNorthwestern University School of Medicine, Chicago, Illinois, United States
A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis
- Conditions
- Interventions
- First Posted Date
- 2013-09-13
- Last Posted Date
- 2018-11-13
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 100
- Registration Number
- NCT01941095
- Locations
- ๐ฌ๐ท
Laiko General Hospital; Dept. of Pathophysiology-Uni of Athens, Athens, Greece
๐ฌ๐ทUni Hospital of Ioannina; Rheumatology, Ioannina, Greece
๐ฌ๐ทGeneral Hospital of Thessaloniki HIPPOKRATIO; Clinical Immunology Unit,2nd Dept of Internal Medicine, Thessaloniki, Greece
Infliximab Top-down in Pediatric Crohn
- Conditions
- Interventions
- First Posted Date
- 2013-06-18
- Last Posted Date
- 2015-07-02
- Lead Sponsor
- Erasmus Medical Center
- Target Recruit Count
- 13
- Registration Number
- NCT01880307
- Locations
- ๐ณ๐ฑ
Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
๐ฎ๐นSapienza University, Rome, Italy
The Efficacy of Enteral Nutrition in Fill of the Treatment Blank Period of the Postoperative Maintain Remission Medication for Crohn's Disease (CD)
- Conditions
- Interventions
- First Posted Date
- 2013-04-04
- Last Posted Date
- 2013-04-04
- Lead Sponsor
- Jinling Hospital, China
- Target Recruit Count
- 100
- Registration Number
- NCT01823042
- Locations
- ๐จ๐ณ
General Surgery Institute,Jinling Hospital, Nanjing, Jiangsu, China
Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease
- First Posted Date
- 2013-03-26
- Last Posted Date
- 2013-03-26
- Lead Sponsor
- Gastroenterology Research of America
- Target Recruit Count
- 65
- Registration Number
- NCT01817972
- Locations
- ๐บ๐ธ
Gastroenterology Research of America, San Antonio, Texas, United States
The Efficacy and Safety of Leflunomide or Azathioprine Therapy in Myasthenia Gravis Patients After Expand Thymectomy
- First Posted Date
- 2012-11-15
- Last Posted Date
- 2022-04-14
- Target Recruit Count
- 290
- Registration Number
- NCT01727193
- Locations
- ๐จ๐ณ
The First Affiliated Hospital, SUN YAT-SEN UNIVERSITY, Guangzhou, Guangdong, China
Rituximab Vasculitis Maintenance Study
- Conditions
- Interventions
- First Posted Date
- 2012-10-02
- Last Posted Date
- 2022-03-18
- Target Recruit Count
- 188
- Registration Number
- NCT01697267
- Locations
- ๐ธ๐ช
Karolinska University Hospital, Stockholm, Sweden
๐ณ๐ฟNorth Shore Hospital, Westlake, Auckland, New Zealand
๐ฌ๐งBrighton and Sussex University Hospitals, Brighton, United Kingdom
Drug Development Updates
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