Teniposide
- Generic Name
- Teniposide
- Drug Type
- Small Molecule
- Chemical Formula
- C32H32O13S
- CAS Number
- 29767-20-2
- Unique Ingredient Identifier
- 957E6438QA
Overview
Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Background
Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Indication
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
Associated Conditions
- Refractory Lymphoblastic Leukemia, Acute, Childhood
Clinical Trials
FDA Approved Products
Singapore Approved Products
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