MedPath

Iobenguane

Generic Name
Iobenguane
Brand Names
Azedra
Drug Type
Small Molecule
Chemical Formula
C8H10IN3
CAS Number
80663-95-2
Unique Ingredient Identifier
35MRW7B4AD

Overview

Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline. Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved on September 19, 2008.

Background

Synthetic guanethidine derivative that locates phaeochromocytomas and neuroblastomas. The radioisotope used can either be iodine-123 for imaging or iodine-131 for destruction of tissues that metabolize noradrenaline. Iodine 123 is a cyclotron-produced radionuclide that decays to Te 123 by electron capture. Images are produced by a I123 MIBG scintigraphy. FDA approved on September 19, 2008.

Indication

Detection of primary and metastatic pheochromocytoma or neuroblastoma

Associated Conditions

  • Metastatic Adrenal Gland Pheochromocytoma
  • Metastatic Neuroblastoma
  • Primary Neuroblastomas
  • Primary Pheochromocytomas
  • Unresectable, locally advanced iobenguane-scan positive Paraganglioma
  • Unresectable, locally advanced iobenguane-scan positive Pheochromocytomas
  • Unresectable, metastatic iobenguane-scan positive Paraganglioma
  • Unresectable, metastatic iobenguane-scan positive Pheochromocytomas

FDA Approved Products

No FDA products found for this drug

Singapore Approved Products

META-IODOBENZYLGUANIDINE (I-131) INJECTION FOR THERAPEUTIC USE
Manufacturer:GE HEALTHCARE BUCHLER GMBH & CO KG
Form:INJECTION
Strength:0.185 - 0.740 GBq/ml
Online:Yes
Approved: 2002/05/28
Approval:SIN11963P

Drug Development Updates

Stay informed with timely notifications on clinical trials and research advancements.

© Copyright 2025. All Rights Reserved by MedPath