Iobenguane (Azedra)

概览

Iobenguane is a radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.

作用机制

Structure of iobenguane is similar to noradrenaline so it can be taken up by adrenergic tissue in the adrenal medulla, liver, heart, and spleen. Once taken up by noradrenaline transporters in the adrenergic nerve terminals, it is stored in the presynaptic storage vesicles. The radioactive iodine component is responsible for its imaging properties.

适应症

Detection of primary and metastatic pheochromocytoma or neuroblastoma

• Metastatic Adrenal Gland Pheochromocytoma
• Metastatic Neuroblastoma
• Primary Neuroblastomas
• Primary Pheochromocytomas
• Unresectable, locally advanced iobenguane-scan positive Paraganglioma
• Unresectable, locally advanced iobenguane-scan positive Pheochromocytomas
• Unresectable, metastatic iobenguane-scan positive Paraganglioma
• Unresectable, metastatic iobenguane-scan positive Pheochromocytomas