Chlorthalidone
- Generic Name
- Chlorthalidone
- Brand Names
- Edarbyclor, Tenoretic, Thalitone
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11ClN2O4S
- CAS Number
- 77-36-1
- Unique Ingredient Identifier
- Q0MQD1073Q
- Background
Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in t...
- Indication
Chlorthalidone is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy....
- Associated Conditions
- Calcium Nephrolithiasis, Edema, Hypertension
- Associated Therapies
- -
Genetics of Hypertension Associated Treatments (GenHAT)
- First Posted Date
- 2000-09-26
- Last Posted Date
- 2024-04-26
- Lead Sponsor
- Donna Arnett, 257-5678
- Target Recruit Count
- 37939
- Registration Number
- NCT00006294
- Locations
- 🇺🇸
University of Kentucky, Lexington, Kentucky, United States
Systolic Hypertension in the Elderly Program (SHEP)
- Conditions
Trial of Antihypertensive Intervention Management
- Conditions
Diuretics, Hypertension, and Arrhythmias Clinical Trial
- Conditions
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2013-09-19
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 233
- Registration Number
- NCT00000525
Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Treatment of Mild Hypertension Study (TOMHS)
- Conditions
- First Posted Date
- 1999-10-28
- Last Posted Date
- 2016-02-25
- Lead Sponsor
- University of Minnesota
- Registration Number
- NCT00000522
Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study)
- Conditions
Drug Development Updates
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