Esketamine

Generic Name
Esketamine
Brand Names
Spravato
Drug Type
Small Molecule
Chemical Formula
C13H16ClNO
CAS Number
33643-46-8
Unique Ingredient Identifier
50LFG02TXD
Background

Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide. On March 5, 2019, the nasal spray drug, esketamine, also known as Spravato (by Janssen Pharmaceuticals), was approved by the FDA for treatment-resistant major depression.
...

Indication

Esketamine is indicated in combination with an oral antidepressant for the treatment of treatment-resistant depression in adults. It is also indicated for the treatment of depressive symptoms in adults with major depressive disorder experiencing acute suicidal ideation or behaviour.

Associated Conditions
Major Depressive Disorder (MDD), Major depressive disorder, recurrent episode, Pain
Associated Therapies
Intubation
Clinical Trials
Related News

Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort

First Posted Date
2024-05-03
Last Posted Date
2024-06-07
Lead Sponsor
Peking University First Hospital
Target Recruit Count
1740
Registration Number
NCT06399185
Locations
🇨🇳

Peking University First Hospital, Beijing, Beijing, China

🇨🇳

Peking University Shenzhen Hospital, Shenzhen, Guangdong, China

The Effect of Esketamine on Sleep Disturbance

Not Applicable
Not yet recruiting
Conditions
Sleep Disturbance
Interventions
Drug: normal saline
Drug: Esketamine
First Posted Date
2024-04-29
Last Posted Date
2024-05-01
Lead Sponsor
Tianjin Medical University General Hospital
Target Recruit Count
200
Registration Number
NCT06388824
Locations
🇨🇳

Tianjin medical university general hospital, Tianjin, China

🇨🇳

Tianjin Medical University General Hospital, Tianjin, China

Effect of Esketamine on Conscious State in Patients With pDoC

Not Applicable
Recruiting
Conditions
Esketamine
Consciousness Disorders
Interventions
Drug: normal saline
Drug: Esketamine
First Posted Date
2024-04-29
Last Posted Date
2024-07-30
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
116
Registration Number
NCT06389344
Locations
🇨🇳

Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China

Esketamine Anesthesia in Thoracic Surgery

Not Applicable
Not yet recruiting
Conditions
General Anesthesia
Thoracic Surgery
Interventions
Drug: Esketamine
Drug: Sufentanil
First Posted Date
2024-03-15
Last Posted Date
2024-05-17
Lead Sponsor
Hui Xu
Target Recruit Count
84
Registration Number
NCT06310785

The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery

Not Applicable
Recruiting
Conditions
Postoperative Pain
Interventions
Drug: saline
Drug: Esketamine
First Posted Date
2024-03-08
Last Posted Date
2024-03-08
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
108
Registration Number
NCT06300944
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

ED50 of Esketamine for Laser Treatment in Children

Not Applicable
Not yet recruiting
Conditions
Anesthesia
Interventions
Drug: Esketamine
First Posted Date
2024-03-05
Last Posted Date
2024-03-05
Lead Sponsor
Air Force Military Medical University, China
Target Recruit Count
40
Registration Number
NCT06294639

Esketamine vs Remimazolam for Postoperative Sleep Disturbance and Anxiety

Not Applicable
Recruiting
Conditions
Sleep Disturbance
Interventions
Drug: normal Saline
Drug: Esketamine
Drug: Remimazolam
First Posted Date
2024-02-29
Last Posted Date
2024-03-05
Lead Sponsor
Tianjin Medical University General Hospital
Target Recruit Count
300
Registration Number
NCT06284668
Locations
🇨🇳

Tianjin Medical University General Hospital, Tianjin, China

Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients

First Posted Date
2023-10-31
Last Posted Date
2024-04-16
Lead Sponsor
Tianjin Medical University General Hospital
Target Recruit Count
400
Registration Number
NCT06108830
Locations
🇨🇳

Tianjin Medical University General Hospital, Tianjin, China

Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes

First Posted Date
2023-10-17
Last Posted Date
2023-10-19
Lead Sponsor
Peking University First Hospital
Target Recruit Count
312
Registration Number
NCT06087510
Locations
🇨🇳

Beijing University First Hospital, Beijing, Beijing, China

Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients

Early Phase 1
Not yet recruiting
Conditions
Anxiety-depression
Interventions
Drug: Esketamine
First Posted Date
2023-10-10
Last Posted Date
2023-10-10
Lead Sponsor
Henan Provincial People's Hospital
Target Recruit Count
200
Registration Number
NCT06073015
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