雌酮 (Estragyn)

概览

Estrone is an estrogen used to treat perimenopausal and postmenopausal symptoms.

作用机制

Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) release from the anterior pituitary.

适应症

For management of perimenopausal and postmenopausal symptoms.

• Vulvo Vaginal Atrophy