Estrone
- Generic Name
- Estrone
- Brand Names
- Estragyn
- Drug Type
- Small Molecule
- Chemical Formula
- C18H22O2
- CAS Number
- 53-16-7
- Unique Ingredient Identifier
- 2DI9HA706A
Overview
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Background
Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Indication
For management of perimenopausal and postmenopausal symptoms.
Associated Conditions
- Vulvo Vaginal Atrophy
Clinical Trials
FDA Approved Products
Singapore Approved Products
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