MedPath

Cannabidiol

Generic Name
Cannabidiol
Brand Names
Epidiolex, Sativex, Epidyolex
Drug Type
Small Molecule
Chemical Formula
C21H30O2
CAS Number
13956-29-1
Unique Ingredient Identifier
19GBJ60SN5
Background

Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses . CBD's exact place within medical practice is still currently hotly debated, however as the body of evidence grows and legislation changes to reflect its wide-spread use, public and medical opinion have changed significantly with regards to its usefulness in a number of medical conditions ranging from anxiety to epilepsy.

From a pharmacological perspective, Cannabis' (and CBD's) diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids, a class of compounds that act upon endogenous cannabinoid receptors of the body . Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. Through its modulation of neurotransmitter release, the endocannabinoid system regulates cognition, pain sensation, appetite, memory, sleep, immune function, and mood among many other bodily systems. These effects are largely mediated through two members of the G-protein coupled receptor family, cannabinoid receptors 1 and 2 (CB1 and CB2). CB1 receptors are found in both the central and peripheral nervous systems, with the majority of receptors localized to the hippocampus and amygdala of the brain. Physiological effects of using cannabis make sense in the context of its receptor activity as the hippocampus and amygdala are primarily involved with regulation of memory, fear, and emotion. In contrast, CB2 receptors are mainly found peripherally in immune cells, lymphoid tissue, and peripheral nerve terminals .

Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two types of cannabinoids found naturally in the resin of the marijuana plant, both of which interact with the cannabinoid receptors that are found throughout the body. Although THC and CBD have been the most studied cannabinoids, there are many others identified to date including cannabinol (CBN), cannabigerol (CBG), Cannabidivarin (CBDV), and Tetrahydrocannabivarin (THCV) that can be found within the medical cannabis . While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms of THC like Dronabinol or Nabilone), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers.

The primary psychoactive component of Cannabis, delta 9-tetrahydrocannabinol (Δ9-THC), demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. This activity results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body . Allosteric regulation is achieved through the modulation of receptor activity on a functionally distinct site from the agonist or antagonist binding site which is clinically significant as direct agonists (such as THC) are limited by their psychomimetic effects such as changes to mood, memory, and anxiety.

In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) .

CBD is currently available in Canada within a 1:1 formulation with tetrahydrocannbinol (THC) (as the formulation known as "nabiximols") as the brand name product Sativex. It is approved for use as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS). Sativex was also given a conditional Notice of Compliance (NOC/c) for use as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis and as adjunctive analgesic treatment for moderate to severe pain in adult patients with advanced cancer .

In April 2018, a Food and Drug Administration advisory panel unanimously recommended approval of Epidiolex (cannabidiol oral solution) for the treatment of two rare forms of epilepsy - Lennox-Gastaut syndrome and Dravet syndrome, which are among the two most difficult types of epilepsy to treat . Epidiolex was granted Orphan Drug designation as well as Fast Track Approval from the FDA for further study in these hard to treat conditions. Notably, phase 3 clinical trials of Epidiolex have demonstrated clinically significant improvement in Lennox-Gastaut syndrome and Dravet syndrome . On June 25th, 2018, Epidiolex was approved by the FDA to be the first CBD-based product available on the US market.

Indication

When used in combination with delta-9-tetrahydrocannabinol as the product Sativex, cannabidiol was given a standard marketing authorization (ie. a Notice of Compliance (NOC)) by Health Canada for the following indications:

1) as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy ;

Due to the need for confirmatory studies to verify the clinical benefit coupled with the promising nature of the clinical evidence, Sativex was also given a Notice of Compliance with Conditions (NOC/c) by Health Canada for the following indications:

1) as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis;

2) as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain .

Associated Conditions
Multiple Sclerosis, Seizures, Severe Pain, Moderate Pain
Associated Therapies
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The Effects of CBD Isolate on Menstrual-Related Symptoms

Phase 2
Completed
Conditions
Menstrual Discomfort
Interventions
First Posted Date
2023-01-11
Last Posted Date
2023-01-11
Lead Sponsor
Canopy Growth Corporation
Target Recruit Count
33
Registration Number
NCT05679830
Locations
🇺🇸

James Madison University, Harrisonburg, Virginia, United States

Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Early Phase 1
Withdrawn
Conditions
Chemotherapy-Induced Peripheral Neuropathy
Breast Carcinoma
Colon Carcinoma
Interventions
Drug: Placebo Administration
Drug: Cannabidiol
Other: Questionnaire Administration
Drug: Delta-8-Tetrahydrocannabinol
First Posted Date
2023-01-05
Last Posted Date
2024-08-09
Lead Sponsor
City of Hope Medical Center
Registration Number
NCT05672342
Locations
🇺🇸

City of Hope Medical Center, Duarte, California, United States

Evaluation of the Efficacy of CANNABIDIOL on the Pruritus in Children With Hereditary Epidermolysis Bullosa

Phase 2
Completed
Conditions
Hereditary Epidermolysis Bullosa
Interventions
First Posted Date
2022-12-15
Last Posted Date
2024-01-24
Lead Sponsor
Assistance Publique - Hôpitaux de Paris
Target Recruit Count
10
Registration Number
NCT05651607
Locations
🇫🇷

Hôpital Necker Enfants Malades, Paris, France

Investigating the Effects of Cannabidiol on Social Anxiety Disorder

Phase 4
Not yet recruiting
Conditions
Phobia, Social
Interventions
Drug: Placebo
Drug: Cannabidiol
First Posted Date
2022-12-13
Last Posted Date
2024-08-22
Lead Sponsor
Massachusetts Institute of Technology
Target Recruit Count
50
Registration Number
NCT05649059
Locations
🇺🇸

Massachusetts General Hospital, Boston, Massachusetts, United States

🇺🇸

Massachusetts Institute of Technology, Cambridge, Massachusetts, United States

Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.

Phase 1
Withdrawn
Conditions
Periodontitis, Adult
Inflammation Gum
Interventions
Drug: cannabidiol
Device: floss
Device: proxabrush
First Posted Date
2022-12-12
Last Posted Date
2023-12-04
Lead Sponsor
University of Nebraska
Registration Number
NCT05646459

Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial

Phase 2
Recruiting
Conditions
Brain Injuries, Traumatic
Interventions
Drug: Placebo
Drug: Cannabidiol
First Posted Date
2022-11-30
Last Posted Date
2024-01-10
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
120
Registration Number
NCT05632627
Locations
🇺🇸

University of Colorado Anschutz, Aurora, Colorado, United States

Alcohol Use Disorder and Cannabidiol

Phase 2
Recruiting
Conditions
Alcohol Use Disorder
Interventions
Drug: Placebo
Drug: Cannabidiol
First Posted Date
2022-11-14
Last Posted Date
2024-09-30
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
180
Registration Number
NCT05613608
Locations
🇺🇸

University of Colorado Anschutz, Aurora, Colorado, United States

Cannabidiol as a Treatment for Social Anxiety Disorder (R61)

Phase 2
Recruiting
Conditions
Social Anxiety Disorder
Interventions
Drug: Placebo
Drug: Cannabidiol
First Posted Date
2022-10-07
Last Posted Date
2024-10-03
Lead Sponsor
NYU Langone Health
Target Recruit Count
60
Registration Number
NCT05571592
Locations
🇺🇸

NYU Langone Health, New York, New York, United States

Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

Phase 2
Recruiting
Conditions
Cannabis
THC
HIV
Neuroinflammatory Disease
Neuroinflammatory Response
Microbiome
Interventions
First Posted Date
2022-08-25
Last Posted Date
2024-11-14
Lead Sponsor
University of California, San Diego
Target Recruit Count
90
Registration Number
NCT05514899
Locations
🇺🇸

HIV Neurobehavioral Research Program (HNRP), San Diego, California, United States

Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

Phase 2
Recruiting
Conditions
Bipolar Disorder
Interventions
First Posted Date
2022-07-14
Last Posted Date
2024-03-08
Lead Sponsor
Mclean Hospital
Target Recruit Count
25
Registration Number
NCT05457465
Locations
🇺🇸

McLean Hospital, Belmont, Massachusetts, United States

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