Sivelestat
- Generic Name
- Sivelestat
- Drug Type
- Small Molecule
- Chemical Formula
- C20H22N2O7S
- CAS Number
- 127373-66-4
- Unique Ingredient Identifier
- DWI62G0P59
- Background
Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.
- Indication
用于治疗伴有全身炎症反应综合征的急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）。
Efficacy and Safety of Sivelestat Sodium and Dexamethasone in the Treatment of ARDS
Not Applicable
Recruiting
- Conditions
- Acute Respiratory Distress Syndrome
- Interventions
- First Posted Date
- 2024-04-29
- Last Posted Date
- 2024-06-04
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 300
- Registration Number
- NCT06387823
- Locations
- 🇨🇳
Luoyang Central Hospital, Luoyang, Henan, China
🇨🇳Peking Union Medical College Hospital, Beijing, Beijing, China
🇨🇳Yanan University Affiliated Hospital, Yanan, Shaanxi, China
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial
Phase 3
Not yet recruiting
- Conditions
- Sepsis
- Interventions
- Drug: Low molecular weight heparinDrug: Recombinant humanThrombomodulin( rhTM)Biological: Fresh frozen plasmaOther: Usual care
- First Posted Date
- 2024-04-24
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 2000
- Registration Number
- NCT06381661
Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Respiratory Distress Syndrome After Cardiac Surgery :a Single Centre Random Control Trial.
- First Posted Date
- 2024-02-26
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Target Recruit Count
- 384
- Registration Number
- NCT06276569
Clinical Effects of Sivelestat Sodium on Improving ARDS in Patients With COVID-19
Completed
- Conditions
- ARDS Due to Disease Caused by SARS Co-V-2
- Interventions
- Drug: Control
- First Posted Date
- 2024-01-23
- Last Posted Date
- 2024-01-23
- Lead Sponsor
- The First Hospital of Jilin University
- Target Recruit Count
- 387
- Registration Number
- NCT06218862
- Locations
- 🇨🇳
Yuting Li, Changchun, None Selected, China
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Not Applicable
Recruiting
- Conditions
- Aortic DissectionSystemic Inflammatory Response SyndromeCardiovascular Diseases (CVD)
- Interventions
- Drug: Blank control
- First Posted Date
- 2024-01-08
- Last Posted Date
- 2024-11-22
- Lead Sponsor
- Nanjing Medical University
- Target Recruit Count
- 500
- Registration Number
- NCT06195267
- Locations
- 🇨🇳
Beijing Anzhen Hospital, Beijing, China
🇨🇳The First Affiliated Hospital of Nanjing Medical University and Jiang ye-fan, Nanjing, China
A Pilot Study of Sivelestat Sodium to Shorten Mechanical Ventilation in Acute Aortic Dissection
Not Applicable
Not yet recruiting
- Conditions
- Acute Aortic Dissection
- Interventions
- Drug: Placebo was given intravenously
- First Posted Date
- 2023-05-25
- Last Posted Date
- 2023-05-25
- Lead Sponsor
- Xiaotong Hou
- Target Recruit Count
- 30
- Registration Number
- NCT05874700
- Locations
- 🇨🇳
Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing, Beijing, China
Sivelestat for Acute Respiratory Distress Syndrome Due to COVID-19
Not Applicable
Not yet recruiting
- Conditions
- Respiratory Infection VirusRespiratory Failure
- Interventions
- Drug: The Placebo
- First Posted Date
- 2023-01-25
- Last Posted Date
- 2023-01-25
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 238
- Registration Number
- NCT05697016
Neutrophil Elastase Inhibitor in Treatment of ARDS Patients With Mechanical Ventilation Caused by Sepsis
Not Applicable
Not yet recruiting
- Conditions
- Acute Respiratory Distress Syndrome
- Interventions
- First Posted Date
- 2023-01-05
- Last Posted Date
- 2023-01-05
- Lead Sponsor
- The First Hospital of Jilin University
- Target Recruit Count
- 100
- Registration Number
- NCT05672472
Improvement of Pulmonary Insufficiency After Aortic Dissection With Sivelestat Sodium
Not Applicable
Not yet recruiting
- Conditions
- Aortic DissectionAcute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
- Interventions
- First Posted Date
- 2022-04-25
- Last Posted Date
- 2022-04-25
- Target Recruit Count
- 168
- Registration Number
- NCT05343338
- Locations
- 🇨🇳
First Affiliated Hospital of Xian Jiaotong University, Xi'an, Shaanxi, China
Effect of Early Treatment With Sivelestat Sodium in ARDS Patients
- Conditions
- Inflammatory ResponseARDS
- Interventions
- First Posted Date
- 2021-08-25
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- Nanfang Hospital, Southern Medical University
- Target Recruit Count
- 560
- Registration Number
- NCT05020210
- Locations
- 🇨🇳
Southern medical university Nanfang hospital, Guangzhou, China
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