Overview
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Associated Conditions
- Cardiac Arrest
- Severe hypotension
- Shock
- Acute, severe Hypotension
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2017/11/14 | Phase 3 | UNKNOWN | Central Hospital, Nancy, France | ||
2017/11/01 | Phase 4 | Completed | |||
2017/10/12 | Not Applicable | UNKNOWN | |||
2017/10/05 | Phase 3 | Suspended | |||
2017/09/19 | Not Applicable | Completed | Szeged University | ||
2017/08/14 | Phase 4 | UNKNOWN | |||
2017/07/31 | Phase 4 | Completed | |||
2017/07/12 | Phase 3 | Completed | |||
2017/06/09 | Phase 4 | Completed | |||
2017/05/23 | Phase 4 | Completed |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||