Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a symp...
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock
- Conditions
- Interventions
- First Posted Date
- 2024-01-31
- Last Posted Date
- 2024-01-31
- Lead Sponsor
- King's College Hospital NHS Trust
- Target Recruit Count
- 45
- Registration Number
- NCT06234592
- Locations
- 🇬🇧
King's College Hospital, London, United Kingdom
Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2024-01-19
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 90
- Registration Number
- NCT06213935
The Effect of Vasopressor on Pressure Injury Development
- Conditions
- Interventions
- First Posted Date
- 2023-12-08
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- Koç University
- Target Recruit Count
- 148
- Registration Number
- NCT06163352
- Locations
- 🇹🇷
Koç University, Istanbul, None Selected, Turkey
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment in Preeclamptic Patients
- Conditions
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158035
ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment in Preeclamptic Patients
- Conditions
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2024-12-04
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158022
- Locations
- 🇨🇳
General hospital of Ningxia University, Yinchuan, Ningxia, China
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
- Conditions
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158009
ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive Treatment
- Conditions
- Interventions
- First Posted Date
- 2023-12-06
- Last Posted Date
- 2023-12-06
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT06158048
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
- Conditions
- First Posted Date
- 2023-11-07
- Last Posted Date
- 2024-03-12
- Lead Sponsor
- Region Skane
- Target Recruit Count
- 473
- Registration Number
- NCT06121115
- Locations
- 🇸🇪
Skåne University Hospital, Malmö, Sweden
Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction
- Conditions
- Interventions
- First Posted Date
- 2023-10-12
- Last Posted Date
- 2024-01-17
- Lead Sponsor
- Algemeen Ziekenhuis Maria Middelares
- Target Recruit Count
- 82
- Registration Number
- NCT06080178
- Locations
- 🇧🇪
AZ Maria Middelares, Ghent, East Flanders, Belgium
Vasopressor Outcomes in Spine Surgery
- First Posted Date
- 2023-09-25
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT06053398
- Locations
- 🇺🇸
Clements University Hospital at Dallas, Dallas, Texas, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.