MedPath

Norepinephrine

Generic Name
Norepinephrine
Brand Names
Levophed
Drug Type
Small Molecule
Chemical Formula
C8H11NO3
CAS Number
51-41-2
Unique Ingredient Identifier
X4W3ENH1CV
Background

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication

Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions
Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
Associated Therapies
-
Clinical Trials
Related News

Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction

Not Applicable
Recruiting
Conditions
Norepinephrine
Hypotension
Major Abdominal Surgery
Anesthesiology
Interventions
Drug: Norepinephrine
Drug: Ephedrine
First Posted Date
2022-03-11
Last Posted Date
2023-03-22
Lead Sponsor
Centre Hospitalier Universitaire, Amiens
Target Recruit Count
500
Registration Number
NCT05276596
Locations
🇫🇷

CHU Amiens, Amiens, France

Norepinephrine in Caesarian Section

Phase 4
Recruiting
Conditions
Cesarean Section Complications
Foetal Stress
Hemodynamic Instability
Interventions
Drug: Norepinephrine
First Posted Date
2022-03-03
Last Posted Date
2022-07-27
Lead Sponsor
University Hospital, Antwerp
Target Recruit Count
78
Registration Number
NCT05264870
Locations
🇧🇪

Antwerp University Hospital, Edegem, Belgium

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Early Phase 1
Recruiting
Conditions
Obesity
Vasodilation
Healthy
Interventions
Drug: Propranolol Hydrochloride
Drug: Isoproterenol
Drug: Phentolamine Mesylate
Drug: Norepinephrine
First Posted Date
2022-02-02
Last Posted Date
2024-02-20
Lead Sponsor
University of Missouri-Columbia
Target Recruit Count
72
Registration Number
NCT05219799
Locations
🇺🇸

University of Missouri, Columbia, Missouri, United States

Hot Flashes and Neurovascular Function in Women

Not Applicable
Recruiting
Conditions
Hot Flashes
Menopause
Vasomotor System; Labile
Interventions
Other: Sympathoexcitatory stressors
Drug: Sodium Nitroprusside
Drug: Acetylcholine
Drug: Terbutaline
Drug: Norepinephrine
First Posted Date
2022-01-18
Last Posted Date
2024-05-24
Lead Sponsor
Mayo Clinic
Target Recruit Count
120
Registration Number
NCT05193968
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Early Vasopressors in Sepsis

Phase 3
Recruiting
Conditions
Sepsis
Interventions
Other: Balanced Crystalloid
Drug: Norepinephrine
First Posted Date
2022-01-05
Last Posted Date
2023-12-21
Lead Sponsor
NHS Greater Glasgow and Clyde
Target Recruit Count
3286
Registration Number
NCT05179499
Locations
🇬🇧

Fairfield General Hospital, Bury, United Kingdom

🇬🇧

Royal Derby Hospital, Derby, United Kingdom

🇬🇧

Glasgow Royal Infirmary, Glasgow, United Kingdom

and more 22 locations

Effects of Vasopressor on the Graft Blood Flow in TRAM

Not Applicable
Completed
Conditions
Flap Necrosis
Flap Ischemia
Blood Flow
Anastomotic Failure of Flap
Interventions
Drug: Phenylephrine
Drug: Norepinephrine
First Posted Date
2021-09-20
Last Posted Date
2023-05-03
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
20
Registration Number
NCT05049278
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension

Not Applicable
Completed
Conditions
Adverse Effect
Interventions
Drug: Norepinephrine
Drug: Phenylephrine
First Posted Date
2021-09-05
Last Posted Date
2023-01-05
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
80
Registration Number
NCT05035888
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia

Not Applicable
Recruiting
Conditions
Hemodynamic Instability
Interventions
Drug: Phenylephrine
Drug: Norepinephrine
First Posted Date
2021-09-05
Last Posted Date
2024-02-02
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
72
Registration Number
NCT05035498
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension

Not Applicable
Conditions
Adverse Effect
Interventions
Drug: Norepinephrine
Drug: Phenylephrine
First Posted Date
2021-09-05
Last Posted Date
2021-09-13
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
80
Registration Number
NCT05035472

Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia

Not Applicable
Completed
Conditions
Hemodynamic Instability
Interventions
Drug: Norepinephrine
Drug: Phenylephrine
First Posted Date
2021-09-05
Last Posted Date
2024-02-02
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
40
Registration Number
NCT05035485
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy