Norepinephrine
- Generic Name
- Norepinephrine
- Brand Names
- Levophed
- Drug Type
- Small Molecule
- Chemical Formula
- C8H11NO3
- CAS Number
- 51-41-2
- Unique Ingredient Identifier
- X4W3ENH1CV
- Background
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
- Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
- Associated Conditions
- Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension
- Associated Therapies
- -
EFFECT OF DIFFERENT NOREPINPHRINE APPLICATION METHODS IN CAESARIANES ON HYPOTENSION AFTER SPINAL ANESTHESIA
- Conditions
- Interventions
- First Posted Date
- 2021-07-06
- Last Posted Date
- 2021-07-06
- Lead Sponsor
- Inonu University
- Target Recruit Count
- 208
- Registration Number
- NCT04951167
- Locations
- 🇹🇷
Inonu Universitesi, Malatya, Turkey
GUARDIAN (NCT04884802) Sub-study, Phenylephrine v. Norepinephrine
- First Posted Date
- 2021-06-22
- Last Posted Date
- 2023-08-30
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 6254
- Registration Number
- NCT04934748
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension
- Conditions
- Interventions
- First Posted Date
- 2021-03-09
- Last Posted Date
- 2021-03-09
- Target Recruit Count
- 80
- Registration Number
- NCT04789005
- Locations
- 🇳🇵
Tribhuvan university teaching hospital, Kathmandu, Bagmati, Nepal
Norepinephrine vs Phenylephrine During General Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2021-03-09
- Last Posted Date
- 2022-05-05
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 2000
- Registration Number
- NCT04789330
- Locations
- 🇺🇸
UCSF Medical Center at Parnassus, San Francisco, California, United States
🇺🇸UCSF Medical Center at Mission Bay, San Francisco, California, United States
🇺🇸Ronald Reagan UCLA Medical Center, Los Angeles, California, United States
The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow
- Conditions
- Interventions
- First Posted Date
- 2021-03-02
- Last Posted Date
- 2021-03-02
- Lead Sponsor
- University Hospital, Linkoeping
- Target Recruit Count
- 90
- Registration Number
- NCT04777383
- Locations
- 🇸🇪
University Hospital Linköping, Linköping, Östergötland, Sweden
Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult
- Conditions
- Interventions
- First Posted Date
- 2020-12-24
- Last Posted Date
- 2022-06-21
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 60
- Registration Number
- NCT04683614
- Locations
- 🇪🇬
Walaa Y Elsabeeny, Cairo, Egypt
Acute Renal Injury After Major Elective Non-Cardiac Surgery
- First Posted Date
- 2020-10-23
- Last Posted Date
- 2021-09-22
- Lead Sponsor
- Istanbul University
- Target Recruit Count
- 425
- Registration Number
- NCT04600271
- Locations
- 🇹🇷
Istanbul University Istanbul Faculty of Medicine Departmant of Anesthesiology and Reanimation, Istanbul, Turkey
Angiotensin 2 for AKI After OLT
- First Posted Date
- 2020-10-19
- Last Posted Date
- 2023-12-21
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 30
- Registration Number
- NCT04592744
- Locations
- 🇺🇸
Michael Y Lin, Los Angeles, California, United States
the Effect of Oral Vasopressors for Liberation From IV Vasopressors in Spinal Shock
- Conditions
- Interventions
- First Posted Date
- 2020-10-14
- Last Posted Date
- 2020-10-14
- Lead Sponsor
- Ahmed talaat ahmed aly
- Target Recruit Count
- 90
- Registration Number
- NCT04586790
- Locations
- 🇪🇬
Ahmed Talaat Ahmed, Assiut, Egypt
Diastolic Performance and Norepinephrine in Spinal-Induced Hypotension for Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2020-09-23
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 40
- Registration Number
- NCT04560634
- Locations
- 🇮🇹
IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy
Drug Development Updates
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