Oxymorphone (Opana)

概览

Oxymorphone is an opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.

作用机制

Oxymorphone interacts predominantly with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. Also, it has been shown that oxymorphone binds to and inhibits GABA inhibitory interneurons via mu-receptors. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.

适应症

For the treatment of moderate-to-severe pain.

• Anxiety
• Severe Pain
• Moderate Pain