DeepMed Research

Colistimethate

Generic Name: Colistimethate

Brand Names: Colobreathe, Coly Mycin M, Xylistin

Drug Type: Small Molecule

Chemical Formula: C_₅₈H_₁₀₅N_₁₆O_₂₈S_₅

CAS Number: 12705-41-8

Unique Ingredient Identifier: DL2R53P963

Background: Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.

Indication: For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Associated Conditions: Bacterial Infections

Clinical Trials

Comparative Study of Clinical Outcomes and Safety Between Colistin and Tigecycline

Phase 4

Active, not recruiting

Conditions: Infection in ICU

Interventions: Drug: Colistimethate Sodium
Drug: Tigecycline

First Posted Date: 2025-03-25

Last Posted Date: 2025-03-25

Lead Sponsor: Beni-Suef University

Target Recruit Count: 132

Registration Number: NCT06893835

Locations: 🇪🇬
Pharmacy, Cairo, Egypt

Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial

Not Applicable

Recruiting

Conditions: Pneumonia, Ventilator-Associated

Interventions: Drug: Colistimethate sodium (CMS)

First Posted Date: 2025-02-19

Last Posted Date: 2025-04-16

Lead Sponsor: Qilu Hospital of Shandong University

Target Recruit Count: 476

Registration Number: NCT06834971

Locations: 🇨🇳
Qilu Hospital of Shandong university, Jinan, Shandong, China

Comparing Tigecycline Vs. Colistimethate in CNS Infections

Not yet recruiting

Conditions: Central Nervous System Infections

Interventions: Drug: Tigecycline (Tygacil)
Drug: Colistimethate sodium (CMS)

First Posted Date: 2024-11-25

Last Posted Date: 2024-11-25

Lead Sponsor: Ain Shams University

Target Recruit Count: 70

Registration Number: NCT06702943

Inhaled Colistin to Prevent Pediatric Ventilator-associated Pneumonia

Phase 2

Not yet recruiting

Conditions: Ventilator Associated Pneumonia

Interventions: Drug: colistimethate sodium
Drug: 0.9% Saline

First Posted Date: 2024-07-05

Last Posted Date: 2024-07-05

Lead Sponsor: University Hospital Fattouma Bourguiba

Target Recruit Count: 100

Registration Number: NCT06488794

A Clinical Trial for the Treatment of Carbapenem Resistant Gram-negative Bacterial Infection With Colistimethate Sodium for Injection

Phase 3

Recruiting

Conditions: Mental Health Issue

Interventions: Drug: Colistimethate sodium for injection
Drug: Meropenem for Injection
Drug: Coly Mycin M Injectable Product

First Posted Date: 2024-01-10

Last Posted Date: 2024-01-10

Lead Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Target Recruit Count: 80

Registration Number: NCT06198764

Locations: 🇨🇳
The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
🇨🇳
Zhongshan Hospital Xiamen University, Xiamen, Fujian, China
🇨🇳
Xiangya Hospital Central South University, Changsha, Hunan, China

and more 29 locations

Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLED

Phase 4

Completed

Conditions: Bacterial Infections

Interventions: Drug: Colistin Sulfomethate

First Posted Date: 2022-10-19

Last Posted Date: 2022-11-28

Lead Sponsor: Mahidol University

Target Recruit Count: 13

Registration Number: NCT05586438

Locations: 🇹🇭
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections

Phase 4

Completed

Conditions: Gram-Negative Bacterial Infections
Pediatric Cancer
Colistin
Colistin Adverse Reaction
MIC

Interventions: Drug: Colistimethate Sodium

First Posted Date: 2018-01-12

Last Posted Date: 2020-09-16

Lead Sponsor: National Cancer Institute, Egypt

Target Recruit Count: 70

Registration Number: NCT03397914

Locations: 🇪🇬
Iman Sidhom, Cairo, Cairo Governorate, Egypt

A Study of DEcolonization in Patients With HAematological Malignancies (DEHAM)

Phase 4

Completed

Conditions: Hematological Infection

Interventions: Drug: Colistimethate Sodium

First Posted Date: 2016-11-17

Last Posted Date: 2017-12-28

Lead Sponsor: Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology

Target Recruit Count: 62

Registration Number: NCT02966457

Locations: 🇧🇾
Republican Center of Hematology and Bone Marrow Transplantation, Minsk, Belarus

Impact of Plasma Levels of Colistin in Patients With Carbapenem Resistant Acinetobacter Baumannii Infection

Completed

Conditions: Acinetobacter Infections

First Posted Date: 2015-06-26

Last Posted Date: 2018-06-26

Lead Sponsor: DongGuk University

Target Recruit Count: 30

Registration Number: NCT02482961

Locations: 🇰🇷
Dongguk University Ilsan Hospital, Goyang, Kyonggido, Korea, Republic of

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-7655A-013)

Phase 3

Completed

Conditions: Bacterial Infections

Interventions: Drug: Colistimethate sodium (CMS)
Drug: Imipenem+Cilastatin/Relebactam
Drug: Placebo to CMS
Drug: Imipenem+Cilastatin

First Posted Date: 2015-05-22

Last Posted Date: 2018-10-19

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 50

Registration Number: NCT02452047

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