Imipenem

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits a longer half-life due to increased binding to plasma proteins. Imipenem is commonly used in combination with cilastatin and is now available in a triple-drug product with cilastatin and relebactam which was recently approved by the FDA. Imipenem was first approved by the FDA in November 1985 as the combination product Primaxin marketed by Merck & Co.

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits a longer half-life due to increased binding to plasma proteins. Imipenem is commonly used in combination with cilastatin and is now available in a triple-drug product with cilastatin and relebactam which was recently approved by the FDA. Imipenem was first approved by the FDA in November 1985 as the combination product Primaxin marketed by Merck & Co.

Imipenem is indicated, in combination with cilastatin with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract, and intra-abdominal as well as septicemia and endocarditis.

• Bacterial Septicemia
• Bone and Joint Infections
• Complicated Intra-Abdominal Infections (cIAIs) caused by Gram-negative Bacteria
• Complicated Urinary Tract Infection
• Complicated Urinary Tract Infection caused by Gram-negative Bacteria
• Endocarditis caused by staphylococcus aureus
• Gynecological Infection
• Intraabdominal Infections
• Lower respiratory tract infection bacterial
• Nosocomial Pneumonia caused by Gram-negative Bacteria
• Pyelonephritis
• Skin and Subcutaneous Tissue Bacterial Infections
• Uncomplicated Urinary Tract Infections
• Ventilator Associated Bacterial Pneumonia caused by Gram-negative Bacteria