MedPath

Linolenic acid

Generic Name
Linolenic acid
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C18H30O2
CAS Number
463-40-1
Unique Ingredient Identifier
0RBV727H71
Background

Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.

Indication

For nutritional supplementation and for treating dietary shortage or imbalance.

Associated Conditions
-
Associated Therapies
Nutritional supplementation
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Ameluz-PDT Leads to Target Lesion Clearance in Superficial Basal Cell Carcinoma

Ameluz (BF-200 ALA) plus photodynamic therapy (PDT) significantly improved lesion clearance in patients with superficial basal cell carcinoma (sBCC) compared to placebo-PDT, according to phase 3 ALA-BCC-CT013 trial results. The trial's primary endpoint showed 65.5% success rate in Ameluz arm vs 4.8% in placebo arm. Complete histological and clinical clearance rates were 75.9% vs 19.0% and 83.4% vs 21.4%, respectively. The FDA submission is expected by end of 2025 after 1-year follow-up.
neurologylive.com
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Polyunsaturated Fats and ALS Disease Progression, CAP-1002 Improves Motor Function in DMD, Lecanemab Granted Traditional Approval

Higher alpha-linolenic acid (ALA) levels linked to longer survival and slower ALS progression. CAP-1002 shows improved cardiac function in DMD patients over 2 years. FDA grants traditional approval to Eisai’s Alzheimer’s drug lecanemab, expanding access for the aging population.
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